Two independent networks of interstitial cells of cajal work cooperatively with the enteric nervous system to create colonic motor patterns.
Two independent networks of interstitial cells of cajal work cooperatively with the enteric nervous system to create colonic motor patterns.
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DOI：
10.3389/fnins.2011.00093
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发表时间：
2011
影响因子：
4.3
通讯作者：
Parsons S
中科院分区：
文献类型：
--
作者：
Huizinga JD;Martz S;Gil V;Wang XY;Jimenez M;Parsons S
结肠的正常运动对生活质量至关重要，使异常结肠功能正常化的努力取得了有限的成功。因此，更好地了解结肠动力的控制系统是必不可少的。我们在这里报告一个假说与支持的实验数据来解释的起源节律性推进结肠运动活动引起的一般膨胀。该理论认为，Cajal间质细胞（ICC）的网络，与肌下神经丛（ICC-SMP）和肌间神经丛（ICC-MP）相关的网络，作为与肠神经系统（ENS）一致的起搏细胞协调传播收缩。ICC-SMP产生无所不在的慢波活动，其引起传播但非推进收缩（“有节奏的传播波纹”），从而增强吸收。ICC-MP产生刺激依赖性循环去极化，在肛门传播并指导推进活动（“节律性推进运动复合体”）。ENS对两种节律性运动模式都不是必需的，因为扩张和药物手段可以在阻断神经活动后产生运动模式，但它提供了体内的主要刺激。支持数据来自对大鼠结肠段的研究，同时通过时空映射的视频记录，管腔内压力和流出量测量来测量运动性。
Normal motility of the colon is critical for quality of life and efforts to normalize abnormal colon function have had limited success. A better understanding of control systems of colonic motility is therefore essential. We report here a hypothesis with supporting experimental data to explain the origin of rhythmic propulsive colonic motor activity induced by general distention. The theory holds that both networks of interstitial cells of Cajal (ICC), those associated with the submuscular plexus (ICC–SMP) and those associated with the myenteric plexus (ICC–MP), orchestrate propagating contractions as pacemaker cells in concert with the enteric nervous system (ENS). ICC–SMP generate an omnipresent slow wave activity that causes propagating but non-propulsive contractions (“rhythmic propagating ripples”) enhancing absorption. The ICC–MP generate stimulus-dependent cyclic depolarizations propagating anally and directing propulsive activity (“rhythmic propulsive motor complexes”). The ENS is not essential for both rhythmic motor patterns since distention and pharmacological means can produce the motor patterns after blocking neural activity, but it supplies the primary stimulus in vivo. Supporting data come from studies on segments of the rat colon, simultaneously measuring motility through spatiotemporal mapping of video recordings, intraluminal pressure, and outflow measurements.
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影响因子：
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