Heparin-Mimicking Polymers: Synthesis and Biological Applications.
Heparin-Mimicking Polymers: Synthesis and Biological Applications.
复制标题
示意肝素的聚合物：合成和生物应用。
DOI：
10.1021/acs.biomac.6b01147
复制
发表时间：
2016-11-14
影响因子：
6.2
通讯作者：
Maynard, Heather D.
中科院分区：
文献类型：
--
作者：
Paluck, Samantha J.;Nguyen, Thi H.;Maynard, Heather D.
肝素是一种天然存在的高度硫酸化多糖，在一系列不同的生物过程中起着关键作用。在治疗上，它通常作为注射液用作各种适应症的抗凝剂，尽管它也以其他形式使用，例如各种生物医学器械上的涂层。由于这种多糖在体内的多种功能，包括抗凝、组织再生、抗炎和蛋白质稳定，以及其使用的缺点，类似的肝素模拟材料也被广泛研究用于治疗应用。本文综述了其中一类材料，即合成的肝素模拟聚合物。与肝素相比，这些聚合物的利用提供了显著的益处，包括由于微调肝素结合基序和其他分子特征而增强治疗功效和减少副作用。概述了各种聚合物的主要类型及其应用。由于开发更广泛的肝素模拟材料将进一步扩大这些聚合物在治疗各种疾病中的影响，未来的方向也进行了讨论。
Heparin is a naturally occurring, highly sulfated polysaccharide that plays a critical role in a range of different biological processes. Therapeutically, it is mostly commonly used as an injectable solution as an anticoagulant for a variety of indications, although it has also been employed in other forms such as coatings on various biomedical devices. Due to the diverse functions of this polysaccharide in the body, including anticoagulation, tissue regeneration, anti-inflammation, and protein stabilization, and drawbacks of its use, analogous heparin-mimicking materials are also widely studied for therapeutic applications. This review focuses on one type of these materials, namely, synthetic heparin-mimicking polymers. Utilization of these polymers provides significant benefits compared to heparin, including enhancing therapeutic efficacy and reducing side effects as a result of fine-tuning heparin-binding motifs and other molecular characteristics. The major types of the various polymers are summarized, as well as their applications. Because development of a broader range of heparin-mimicking materials would further expand the impact of these polymers in the treatment of various diseases, future directions are also discussed.
登录
查看更多内容
DOI：
10.1161/01.atv.14.12.1992
发表时间：
1994-12-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
BENEZRA, M;BENSASSON, SA;VLODAVSKY, I
通讯作者：
VLODAVSKY, I
影响因子：
5.5
作者：
BAILEY, WJ;NI, Z;WU, SR
通讯作者：
WU, SR
影响因子：
6
作者：
Belleney, J;Hélary, G;Migonney, V
通讯作者：
Migonney, V
影响因子：
6.2
作者：
Delplace, Vianney;Tardy, Antoine;Nicolas, Julien
通讯作者：
Nicolas, Julien
通过基于环糊精的超分子的 LbL 组装在聚合物膜上模拟肝素多层涂层
影响因子：
9.5
作者：
Deng, Jie;Liu, Xinyue;Zhao, Changsheng
通讯作者：
Zhao, Changsheng