Family history of prostate and breast cancer and the risk of prostate cancer in the PSA era.
Family history of prostate and breast cancer and the risk of prostate cancer in the PSA era.
复制标题
前列腺癌和乳腺癌家族史以及 PSA 时代患前列腺癌的风险。
DOI：
10.1002/pros.20825
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发表时间：
2008-10-01
期刊：
影响因子：
2.8
通讯作者：
Giovannucci, Edward
中科院分区：
文献类型：
--
作者：
Chen, Yen-Ching;Page, John H.;Chen, Rong;Giovannucci, Edward
前列腺癌（PCa）或乳腺癌（BCa）的家族史与PCa的风险相关，但受影响的家庭成员的风险不一致，PSA时代的数据有限。这项研究包括一个卫生专业人员随访研究的子队列，该研究由1986年至2004年的高度PSA筛查人群组成，确定了3，695例PCa病例。每隔一年和每四年分别进行一次问卷调查和食物频率问卷调查。1990年、1992年和1996年确定了PCa和BCa的家族史。所有统计数据均为双侧。父亲和兄弟的PCa家族史与PCa风险增加2.3倍相关[95%置信区间（CI）=1.76-3.12]。父亲或兄弟在年龄<60岁和≥60岁时诊断为PCa的男性患PCa的风险分别增加2.16倍和1.95倍。PCa家族史与早发性PCa相关（<65岁：RR=2.25，95%CI =1.95-2.60），与晚发性PCa相关性较弱（≥65岁：RR=1.67，95%CI =1.52-1.85）。母亲或姐妹的BCa病史与PCa风险增加1.22倍相关（95% CI=1.08-1.38）。PCa或BCa家族史显著增加PCa风险。这些关联在广泛进行PSA筛查的人群中是明显的。
A family history of prostate cancer (PCa) or breast cancer (BCa) has been associated with the risk of PCa, but the risks were inconsistent in terms of the affected family members, and data in the PSA era are limited. This study included a subcohort of the Health Professionals Follow-Up Study composed of a highly PSA screened population from 1986 to 2004 with 3,695 PCa cases identified. Questionnaires and a food frequency questionnaire were administered every other and every four years, respectively. Family history of PCa and BCa was ascertained in 1990, 1992, and 1996. All statistics were two-sided. A family history of PCa in both a father and brother(s) was associated with a 2.3-fold increased risk of PCa [95% confidence interval (CI)=1.76–3.12]. Men with a father or brother(s) with a PCa diagnosis at age<60 and ≥60 had 2.16- and 1.95-fold increased risk of PCa, respectively. A family history of PCa was related to early-onset PCa (<65 years: RR=2.25, 95% CI=1.95–2.60) and weakly to late-onset PCa (≥65 years: RR=1.67, 95% CI=1.52–1.85). History of BCa in a mother or a sister was associated with a 1.22-fold increased risk of PCa (95% CI=1.08–1.38). A family history of PCa or BCa significantly increases PCa risk. These associations are evident in a population with widespread PSA screening.
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影响因子：
45.3
作者：
Mäkinen, T;Tammela, TLJ;Auvinen, A
通讯作者：
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影响因子：
5
作者：
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3.6
作者：
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通讯作者：
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