Urocortin-Deficient Mice Display Normal Stress-Induced Anxiety Behavior and Autonomic Control but an Impaired Acoustic Startle Response
Urocortin-Deficient Mice Display Normal Stress-Induced Anxiety Behavior and Autonomic Control but an Impaired Acoustic Startle Response
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尿皮质素缺陷的小鼠表现出正常的压力诱发的焦虑行为和自主控制，但声学惊吓反应受损
DOI：
10.1128/mcb.22.18.6605-6610.2002
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发表时间：
2002
影响因子：
5.3
通讯作者：
A. Bradley
中科院分区：
文献类型：
--
作者：
Xiaozhong Wang;Hong Su;L. D. Copenhagen;S. Vaishnav;Fredalina Pieri;C. Shope;W. Brownell;M. De Biasi;R. Paylor;A. Bradley
ABSTRACT Corticotropin-releasing hormone (Crh) plays an important role in modulating physiological and behavioral responses to stress. Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential mediator of stress responses. We generated Ucn-deficient mice using embryonic stem cell technology to determine its role in stress-induced behavioral and autonomic responses. Unlike Crhr1- or Crhr2-deficient mice, Ucn-deficient mice exhibit normal anxiety-like behavior as well as autonomic regulation in response to stress. However, the mutant mice display an impaired acoustic startle response that is not due to an obvious hearing defect. Thus, our results suggest that Ucn does not play an essential role in stress-induced behavioral and autonomic responses. Ucn may modulate the acoustic startle response through the Ucn-expressing neuron projections from the region of the Edinger-Westphal nucleus.
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DOI：
10.1073/pnas.92.7.2969
发表时间：
1995-03-28
影响因子：
11.1
作者：
PERRIN, M;DONALDSON, C;VALE, W
通讯作者：
VALE, W
小鼠和人类尿皮质素基因（Ucn 和 UCN）的结构。
DOI：
10.1006/geno.1998.5292
发表时间：
1998
期刊：
Genomics.
影响因子：
--
作者：
Zhao,L;Donaldson,CJ;Smith,GW;Vale,WW
通讯作者：
Vale,WW
影响因子：
--
作者：
Peter Stenzel;R. A. Kesterson;Wendy Yeung;R. Cone;Marvin B. Rittenberg;M. Stenzel-Poore
通讯作者：
Peter Stenzel;R. A. Kesterson;Wendy Yeung;R. Cone;Marvin B. Rittenberg;M. Stenzel-Poore
影响因子：
2.5
作者：
Carlson, S;Willott, JF
通讯作者：
Willott, JF
DOI：
10.1073/pnas.92.4.1108
发表时间：
1995-02-14
影响因子：
11.1
作者：
KISHIMOTO, T;PEARSE, RV;ROSENFELD, MG
通讯作者：
ROSENFELD, MG