Meiotic spindle assembly and chromosome segregation in oocytes.
Meiotic spindle assembly and chromosome segregation in oocytes.
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DOI：
10.1083/jcb.201607062
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发表时间：
2016-12-05
期刊：
影响因子：
--
通讯作者：
Verlhac MH
中科院分区：
文献类型：
--
作者：
Bennabi I;Terret ME;Verlhac MH
中心体在有丝分裂过程中组织微管纺锤体分离染色体中起着关键作用。Bennabi等综述了在没有中心体的情况下，卵母细胞减数分裂过程中微管纺锤体的形成和染色体分离是如何发生的。卵母细胞积累母体储存物（蛋白质、mRNA、代谢物等）在卵巢中生长，以支持受精后的发育。为了保持这种细胞质母系遗传，它们完成了一项艰巨的任务，即在平均分配染色体的同时不平均分配细胞质。除了这种复杂性，大多数卵母细胞缺乏大多数细胞用来组装和定位纺锤体的主要微管组织中心，即典型的中心体。本文就近年来有关雌配子减数分裂纺锤体组装和染色体排列/分离机制的研究进展进行综述，试图了解卵母细胞减数分裂错误的起源。卵母细胞分裂的挑战看起来确实不是微不足道的，因为在小鼠和人类中，卵母细胞减数分裂都容易发生染色体分离错误，这是频繁流产和先天性缺陷的主要原因。
Centrosomes play a key role in organizing the microtubule spindle that separates chromosomes during mitosis. Bennabi et al. review how microtubule spindle formation and chromosomal segregation also occur in oocytes during cell division by meiosis despite the absence of centrosomes. Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth in the ovary to support development after fertilization. To preserve this cytoplasmic maternal inheritance, they accomplish the difficult task of partitioning their cytoplasm unequally while dividing their chromosomes equally. Added to this complexity, most oocytes, for reasons still speculative, lack the major microtubule organizing centers that most cells use to assemble and position their spindles, namely canonical centrosomes. In this review, we will address recent work on the mechanisms of meiotic spindle assembly and chromosome alignment/segregation in female gametes to try to understand the origin of errors of oocyte meiotic divisions. The challenge of oocyte divisions appears indeed not trivial because in both mice and humans oocyte meiotic divisions are prone to chromosome segregation errors, a leading cause of frequent miscarriages and congenital defects.
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影响因子：
4.5
作者：
Colombié N;Głuszek AA;Meireles AM;Ohkura H
通讯作者：
Ohkura H
影响因子：
3.7
作者：
Brunet S;Dumont J;Lee KW;Kinoshita K;Hikal P;Gruss OJ;Maro B;Verlhac MH
通讯作者：
Verlhac MH
DOI：
10.1083/jcb.201202135
发表时间：
2012-08-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Courtois A;Schuh M;Ellenberg J;Hiiragi T
通讯作者：
Hiiragi T
DOI：
10.1073/pnas.1400568111
发表时间：
2014-04-15
影响因子：
11.1
作者：
Bazzi, Hisham;Anderson, Kathryn V.
通讯作者：
Anderson, Kathryn V.
影响因子：
21.3
作者：
Cullen, CF;Ohkura, H
通讯作者：
Ohkura, H