Pediatric AML: From Biology to Clinical Management.
Pediatric AML: From Biology to Clinical Management.
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DOI：
10.3390/jcm4010127
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发表时间：
2015-01-09
影响因子：
3.9
通讯作者：
van den Heuvel-Eibrink M
中科院分区：
文献类型：
--
作者：
de Rooij JD;Zwaan CM;van den Heuvel-Eibrink M
Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute leukemias. Survival rates have increased over the past few decades to ~70%, due to improved supportive care, optimized risk stratification and intensified chemotherapy. In most children, AML presents as a de novo entity, but in a minority, it is a secondary malignancy. The diagnostic classification of pediatric AML includes a combination of morphology, cytochemistry, immunophenotyping and molecular genetics. Outcome is mainly dependent on the initial response to treatment and molecular and cytogenetic aberrations. Treatment consists of a combination of intensive anthracycline- and cytarabine-containing chemotherapy and stem cell transplantation in selected genetic high-risk cases or slow responders. In general, ~30% of all pediatric AML patients will suffer from relapse, whereas 5%–10% of the patients will die due to disease complications or the side-effects of the treatment. Targeted therapy may enhance anti-leukemic efficacy and minimize treatment-related morbidity and mortality, but requires detailed knowledge of the genetic abnormalities and aberrant pathways involved in leukemogenesis. These efforts towards future personalized therapy in a rare disease, such as pediatric AML, require intensive international collaboration in order to enhance the survival rates of pediatric AML, while aiming to reduce long-term toxicity.
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影响因子：
10.1
作者：
Creutzig, Ursula;Zimmermann, Martin;Kaspers, Gertjan L.
通讯作者：
Kaspers, Gertjan L.
影响因子：
11.4
作者：
Debernardi, S.;Skoulakis, S.;Young, B. D.
通讯作者：
Young, B. D.
影响因子：
6.2
作者：
Cooper, Todd M.;Alonzo, Todd A.;Gerbing, Robert B.;Perentesis, John P.;Whitlock, James A.;Taub, Jeffrey W.;Horton, Terzah M.;Gamis, Alan S.;Meshinchi, Soheil;Loken, Michael R.;Razzouk, Bassem I.
通讯作者：
Razzouk, Bassem I.
影响因子：
11.4
作者：
Balgobind, B. V.;Lugthart, S.;van den Heuvel-Eibrink, M. M.
通讯作者：
van den Heuvel-Eibrink, M. M.
影响因子：
39.2
作者：
BENNETT, JM;CATOVSKY, D;SULTAN, C
通讯作者：
SULTAN, C