Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice.
Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice.
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异步胚胎生殖细胞发育导致出生后卵泡激活的异质性，并可能影响小鼠青春期开始的时间
DOI：
10.1186/s12915-022-01318-y
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发表时间：
2022-05-13
期刊：
影响因子：
5.4
通讯作者：
Zhang, Hua
中科院分区：
文献类型：
--
作者：
Dai, Yanli;Bo, Yingnan;Wang, Peike;Xu, Xueqiang;Singh, Meenakshi;Jia, Longzhong;Zhang, Shuo;Niu, Shudong;Cheng, Kaixin;Liang, Jing;Mu, Lu;Geng, Kaiying;Xia, Guoliang;Wang, Chao;Zhang, Yan;Zhang, Hua
关键词：
卵泡是女性生殖的基本单位，由卵母细胞及其周围的体细胞（前）颗粒细胞（GC）组成。最近的一项研究表明，体细胞前GCs中的信号控制成年卵巢中卵泡的激活（初始募集），但也知道哺乳动物中存在两波卵泡，其发育动力学具有与年龄相关的异质性。虽然这种异质性被提出是至关重要的女性生殖，我们的理解，它是如何产生的，其意义仍然是hailing.ResultsIn目前的研究，通过删除的关键分泌因子KIT配体从preGCs和分析的卵泡细胞发育动力学，我们揭示了不同的模式激活和生长相关的两波卵泡在小鼠卵巢。我们的研究结果证实，激活成人波卵泡启动体preGC和依赖于KIT配体。相比之下，激活的第一波卵泡，这是从卵泡形成前的生殖细胞唤醒，可以发生在出生后的卵巢中的preGC分泌的KIT配体的情况下，似乎是卵母细胞启动。我们还发现，胚胎生殖细胞中磷脂酰肌醇3激酶（PI3K）信号传导和减数分裂过程的不同步活动导致了出生后卵巢卵泡的异质性。此外，我们提供的证据表明，胚胎生殖细胞发育的时间顺序及其相关的第一波卵泡生长相关的青春期开始在femines.ConclusionTogether的时间，我们的研究提供的证据表明，胚胎卵母细胞的异步发育导致出生后的卵泡激活和发育的异质性，并影响青春期开始在女性的时间。
BackgroundOvarian follicles, which are the basic units of female reproduction, are composed of oocytes and surrounding somatic (pre) granulosa cells (GCs). A recent study revealed that signaling in somatic preGCs controlled the activation (initial recruitment) of follicles in the adult ovaries, but it is also known that there are two waves of follicle with age-related heterogeneity in their developmental dynamics in mammals. Although this heterogeneity was proposed to be crucial for female reproduction, our understanding of how it arises and its significance is still elusive.ResultsIn the current study, by deleting the key secreted factor KIT ligand from preGCs and analyzing the follicle cell developmental dynamics, we revealed distinct patterns of activation and growth associated with the two waves of follicles in mouse ovary. Our results confirmed that activation of adult wave follicles is initiated by somatic preGCs and dependent on the KIT ligand. By contrast, activation of first wave follicles, which are awakened from germ cells before follicle formation, can occur in the absence of preGC-secreted KIT ligand in postnatal ovaries and appears to be oocyte-initiated. We also found that the asynchronous activity of phosphatidylinositol 3 kinases (PI3K) signaling and meiotic process in embryonic germ cells lead to the follicle heterogeneity in postnatal ovaries. In addition, we supplied evidence that the time sequence of embryonic germ cell development and its related first wave follicle growth are correlated to the time of puberty onset in females.ConclusionTaken together, our study provides evidence that asynchronous development of embryonic oocytes leads to the heterogeneity of postnatal ovarian follicle activation and development, and affects the timing of onset of puberty in females.
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影响因子：
--
作者：
Liu, Chia-Feng;Liu, Chang;Yao, Humphrey H-C
通讯作者：
Yao, Humphrey H-C
影响因子：
56.9
作者：
Chehab, FF;Mounzih, K;Lim, ME
通讯作者：
Lim, ME
影响因子：
5
作者：
Kubo, Ai;Deardorff, Julianna;Kushi, Lawrence H.
通讯作者：
Kushi, Lawrence H.
DOI：
10.1159/000438874
发表时间：
2016-01-01
期刊：
PUBERTY FROM BENCH TO CLINIC: LESSONS FOR CLINICAL MANAGEMENT OF PUBERTAL DISORDERS
影响因子：
--
作者：
Macedo, Delanie Bulcao;Gontijo Silveira, Leticia Ferreira;Latronico, Ana Claudia
通讯作者：
Latronico, Ana Claudia
影响因子：
3.6
作者：
Mork, Lindsey;Maatouk, Danielle M.;Capel, Blanche
通讯作者：
Capel, Blanche