Spleen-Targeted Glabridin-Loaded Nanoparticles Regulate Polarization of Monocyte/Macrophage (M(o) /M(φ) ) for the Treatment of Cerebral Ischemia-Reperfusion Injury.
Spleen-Targeted Glabridin-Loaded Nanoparticles Regulate Polarization of Monocyte/Macrophage (M(o) /M(φ) ) for the Treatment of Cerebral Ischemia-Reperfusion Injury.
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脾脏 — 靶向光甘草定 — 负载纳米颗粒调节单核细胞/巨噬细胞 (Mo/M Ï ) 的极化，用于治疗脑缺血 — 再灌注损伤
DOI：
10.1002/adma.202204976
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发表时间：
2022-09
影响因子：
29.4
通讯作者：
Cai, Weibo
中科院分区：
文献类型：
--
作者：
Li, Shiyong;Wang, Ye;Wu, Miaojin;Younis, Muhsin H.;Olson, Aeli P.;Barnhart, Todd E.;Engle, Jonathan W.;Zhu, Xingen;Cai, Weibo
在脑缺血再灌注（I-R）损伤过程中，单核细胞/巨噬细胞（Mo/Mφ）向缺血半暗区浸润引起炎症损伤，但也调节半暗区组织修复。Mo/Mφ极化的调节与平衡被认为是治疗脑I-R损伤的潜在靶点。本研究结果表明，光甘草定（Gla）负载纳米粒子（即NPGla-5k）可以有效抑制Mo/Mφ的m1极化，增强m2极化。正电子发射断层扫描（PET）显示，NPGla-5k在静脉注射后可选择性地积聚在脾脏中。经尾静脉注射24 h后，脾脏靶向Cy5-NPGla-5k可与外周半暗区巨噬细胞共定位。有趣的是，NPGla-5k治疗可以减少炎症损伤，保护垂死的神经元，改善神经系统功能。脾靶向NPGla-5k对小鼠脑I-R损伤的保护作用，有助于探索其在脑I-R损伤患者临床治疗中的应用。光甘草定（Gla）负载纳米颗粒（NPGla-5k）可以选择性地将Gla输送到脾脏，调节单核细胞/巨噬细胞（Mo/Mφ）的极化。NPGla-5k通过抑制Mo/Mφ介导的炎症损伤，增强其修复作用，改善脑I-R损伤小鼠神经系统功能。
During cerebral ischemia-reperfusion (I-R) injury, the infiltration of monocyte/macrophages (Mo/Mφ) into the ischemic penumbra causes inflammatory damage but also regulates tissue repair in the penumbra. The regulation and balance of Mo/Mφ polarization has been considered as a potential therapeutic target for treating cerebral I-R injury. Herein, our findings demonstrated that glabridin (Gla)-loaded nanoparticles (i.e. NPGla-5k) could effectively inhibit M1-polarization and enhance M2-polarization of Mo/Mφ. Positron emission tomography (PET) imaging showed that NPGla-5k could selectively accumulate in the spleen following intravenous injection. Spleen-targeted Cy5-NPGla-5k can colocalize with peripheral macrophages in the penumbra at 24 h after tail vein injection. Interestingly, NPGla-5k treatment could reduce inflammatory damage, protect dying neurons and improve nervous system function. The protective effect of spleen-targeted NPGla-5k against cerebral I-R injury in mice encourages an exploration of their use for clinical treatment of patients with cerebral I-R injury. Glabridin (Gla)-loaded nanoparticle (NPGla-5k) can selectively deliver Gla to the spleen and regulate the polarization of monocyte/macrophages (Mo/Mφ). By inhibiting Mo/Mφ mediated inflammatory damage and enhancing its repairing effect, NPGla-5k treatment improve nervous system function in mice with cerebral I-R injury.
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DOI：
10.1016/j.bbadis.2014.12.019
发表时间：
2015-05-01
影响因子：
6.2
作者：
Penas, Federico;Mirkin, Gerardo A.;Goren, Nora B.
通讯作者：
Goren, Nora B.
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影响因子：
29.4
作者：
Lu, Yifei;Li, Chao;Jiang, Chen
通讯作者：
Jiang, Chen
影响因子：
4.3
作者：
Mitchell, Andrew J.;Roediger, Ben;Weninger, Wolfgang
通讯作者：
Weninger, Wolfgang
影响因子：
20.1
作者：
Chawla A
通讯作者：
Chawla A
影响因子：
12.8
作者：
Hucke, Stephanie;Eschborn, Melanie;Klotz, Luisa
通讯作者：
Klotz, Luisa