PPARα signaling in the hippocampus: crosstalk between fat and memory.
PPARα signaling in the hippocampus: crosstalk between fat and memory.
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DOI：
10.1007/s11481-014-9582-9
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发表时间：
2015-03
影响因子：
6.2
通讯作者：
Pahan, Kalipada
中科院分区：
文献类型：
--
作者：
Roy, Avik;Pahan, Kalipada
海马体的主要功能是产生、组织和存储记忆。这是一个复杂的过程，由一组分子协调，称为可塑性相关分子。为了在转录水平上控制这些不同的可塑性相关分子，我们被赋予了cAMP反应元件结合蛋白(CREB)，也被称为记忆的主要调节因子。有趣的是，我们已经看到这个主调控因子在海马区的转录水平上受到过氧化体增殖物激活受体α(PPARα)的调控，PPAR是一种核激素受体家族转录因子，已知控制肝脏中脂肪酸的代谢，可能是脂肪和记忆之间的串扰。尽管肝脏PPARα不直接控制海马区CREB，但这为改善海马区功能和通过PPARα配体抵抗记忆丧失以及维持海马区正常水平的PPARα提供了重要的可能性。
Major functions of the hippocampus are to generate, organize and store memory. This is a complex process, which is orchestrated by a group of molecules, called plasticity-related molecules. To control these various plasticity-related molecules at the transcriptional level, we have been endowed with cAMP response element-binding protein (CREB), also known as a master regulator of memory. Interestingly, we have seen that this master regulator is regulated at the transcriptional level in the hippocampus by peroxisome proliferator-activated receptor α (PPARα), a nuclear hormone receptor family transcription factor that is known to control the metabolism of fatty acids in the liver, underlying a possible crosstalk between fat and memory. Although liver PPARα does not directly control hippocampal CREB, this opens up an important possibility to improve hippocampal functions and to be resistant to memory loss by PPARα ligands and maintaining normal levels of PPARα in the hippocampus.
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影响因子：
64.8
作者：
Fu, J;Gaetani, S;Piomelli, D
通讯作者：
Piomelli, D
DOI：
10.1073/pnas.0903038106
发表时间：
2009-05-12
影响因子：
11.1
作者：
Campolongo, Patrizia;Roozendaal, Benno;Piomelli, Daniele
通讯作者：
Piomelli, Daniele
影响因子：
64.8
作者：
Kersten, S;Desvergne, B;Wahli, W
通讯作者：
Wahli, W
影响因子：
64.5
作者：
Nagy, L;Kao, HY;Evans, RM
通讯作者：
Evans, RM
影响因子：
6.1
作者：
Tugwood, JD;Holden, PR;Roberts, RA
通讯作者：
Roberts, RA