An Analysis of IL-10, IL-17A, IL-17RA, IL-23A and IL-23R Expression and Their Correlation with Clinical Course in Patients with Psoriasis.
An Analysis of IL-10, IL-17A, IL-17RA, IL-23A and IL-23R Expression and Their Correlation with Clinical Course in Patients with Psoriasis.
复制标题
银屑病患者IL-10、IL-17 A、IL-17 RA、IL-23 A和IL-23 R的表达及其与临床病程的关系
DOI：
10.3390/jcm10245834
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发表时间：
2021-12-13
影响因子：
3.9
通讯作者：
Woźniacka A
中科院分区：
文献类型：
--
作者：
Kutwin M;Migdalska-Sęk M;Brzeziańska-Lasota E;Zelga P;Woźniacka A
作为最常见的皮肤炎性疾病之一，银屑病是一个经常的研究课题。它被认为是一种T细胞依赖性免疫疾病，其发病机制受细胞因子如IL-10、IL-17 A、IL-17 RA、IL-23 A和IL-23 R的影响。本研究通过PASI、BSA和DLQI量表评估选定基因的表达是否与银屑病的临床病程相关。从60名银屑病患者和24名健康对照中获得皮肤活检和血液用于RNA分离。对这些细胞进行IL-10、IL-17 A、IL-17 RA、IL-23 A和IL-23 R基因的RT-PCR。结果表示为RQ值。与对照组相比，银屑病皮肤中IL-17 A和IL-23 R表达水平较高，而IL-10表达较低。IL-23 A的RQ与PASI指数呈正相关。银屑病皮肤的特征在于IL-17 A和IL-23 R的表达升高和IL-10的表达降低。提示这些细胞因子可能参与银屑病的发病机制，但其表达失衡的确切原因尚需进一步研究。
Being one of the most common dermatological inflammatory disorders, psoriasis is a frequent subject of research. It is considered to be a T cell-dependent immune disease whose pathogenesis is influenced by cytokines, such as IL-10, IL-17A, IL-17RA, IL-23A and IL-23R. The present study examines whether the expression of selected genes is correlated with the clinical course of psoriasis, assessed by the PASI, BSA and DLQI scales. Skin biopsies and blood from 60 patients with psoriasis and 24 healthy controls were obtained for RNA isolation. These were subjected to RT-PCR for IL-10, IL-17A, IL-17RA, IL-23A and IL-23R genes. The results were presented as an RQ value. IL-17A and IL-23R expression levels were higher in psoriatic skin compared to controls, while IL-10 expression was lower. A positive correlation was also found between RQ for IL-23A and PASI index. Psoriatic skin is characterised by elevated expression of IL-17A and IL-23R and decreased expression of IL-10. This indicates that the selected cytokines may be one of the factors involved in the pathogenesis and pathomechanism of psoriasis, but more studies need to be made before we can elucidate the exact reason for the unbalance in cytokine expression levels.
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影响因子：
15.3
作者：
D'Andrea, A;Aste-Amezaga, M;Valiante, N M;Ma, X;Kubin, M;Trinchieri, G
通讯作者：
Trinchieri, G
影响因子：
5.4
作者：
Di Meglio, Paola;Villanova, Federica;Nestle, Frank O.
通讯作者：
Nestle, Frank O.
影响因子：
13.8
作者：
Blauvelt, Andrew;Gooderham, Melinda;Reich, Kristian
通讯作者：
Reich, Kristian
影响因子：
4.6
作者：
Arican O;Aral M;Sasmaz S;Ciragil P
通讯作者：
Ciragil P
DOI：
10.1084/jem.20060244
发表时间：
2006-11-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan JR;Blumenschein W;Murphy E;Diveu C;Wiekowski M;Abbondanzo S;Lucian L;Geissler R;Brodie S;Kimball AB;Gorman DM;Smith K;de Waal Malefyt R;Kastelein RA;McClanahan TK;Bowman EP
通讯作者：
Bowman EP