Aptamers as both drugs and drug-carriers.
Aptamers as both drugs and drug-carriers.
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DOI：
10.1155/2014/697923
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发表时间：
2014
影响因子：
--
通讯作者：
Ashrafuzzaman M
中科院分区：
文献类型：
--
作者：
Ashrafuzzaman M
适体是短核酸寡核苷酸。它们既可以作为药物，也可以作为药物载体。它们作为诊断工具的用途也很明显。它们可以使用各种实验、理论和计算技术生成。通过使用核酸文库的迭代筛选的指数富集的配体的系统进化是流行的实验技术。另一种方法是基于熵的种子和生长策略，它设计适体模板以特异性地结合到靶标上。适体被预测在生产一般药物和偶尔用于某些疾病（如癌症、阿尔茨海默病等）的治疗诊断药物方面非常有用。它们结合各种靶点，如脂质、核酸、蛋白质、小有机化合物，甚至整个生物体。适体还可以作为药物载体或纳米颗粒，帮助药物在特定的靶区域释放。由于更好的靶特异性物理结合性质，适体引起更少的脱靶毒性效应。因此，对基于适体的药物、药物载体、甚至诊断工具的搜索正在快速扩展。生物物理特性的适体，能量背后的适体运输的药物，以及随之而来的生物学意义的目标特异性结合现象将进行讨论。这篇综述将为新药发现和药物递送开辟道路。
Aptamers are short nucleic acid oligos. They may serve as both drugs and drug-carriers. Their use as diagnostic tools is also evident. They can be generated using various experimental, theoretical, and computational techniques. The systematic evolution of ligands by exponential enrichment which uses iterative screening of nucleic acid libraries is a popular experimental technique. Theory inspired methodology entropy-based seed-and-grow strategy that designs aptamer templates to bind specifically to targets is another one. Aptamers are predicted to be highly useful in producing general drugs and theranostic drugs occasionally for certain diseases like cancer, Alzheimer's disease, and so on. They bind to various targets like lipids, nucleic acids, proteins, small organic compounds, and even entire organisms. Aptamers may also serve as drug-carriers or nanoparticles helping drugs to get released in specific target regions. Due to better target specific physical binding properties aptamers cause less off-target toxicity effects. Therefore, search for aptamer based drugs, drug-carriers, and even diagnostic tools is expanding fast. The biophysical properties in relation to the target specific binding phenomena of aptamers, energetics behind the aptamer transport of drugs, and the consequent biological implications will be discussed. This review will open up avenues leading to novel drug discovery and drug delivery.
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影响因子：
3.4
作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
Proceedings of the American Thoracic Society
影响因子：
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10.1166/jctn.2012.2062
发表时间：
2012-04-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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