The epigenetic implication in coronavirus infection and therapy.
The epigenetic implication in coronavirus infection and therapy.
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DOI：
10.1186/s13148-020-00946-x
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发表时间：
2020-10-21
影响因子：
5.7
通讯作者：
Gaetano C
中科院分区：
文献类型：
--
作者：
Atlante S;Mongelli A;Barbi V;Martelli F;Farsetti A;Gaetano C
表观遗传学是一个相对较新的科学领域，研究与可遗传表型变化相关的遗传和非遗传方面，通常由环境和代谢因素引起。在宿主中，表观遗传机制可以通过一系列可逆的表观遗传修饰来调节基因表达，如组蛋白甲基化和乙酰化、DNA/RNA甲基化、染色质重塑和非编码RNA。冠状病毒病19（COVID-19）是一种高度传播和致病的病毒感染。在中国武汉出现并在全球传播的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）导致了它。COVID-19的严重程度和后果在很大程度上取决于患者的年龄和健康状况。本文就病毒如何调控宿主表观基因组进行综述和比较分析。我们将主要关注高致病性呼吸道RNA病毒感染，如冠状病毒。在这种情况下，表观遗传学改变可能在冠状病毒疾病并发症的发生中发挥重要作用。尽管许多治疗方法正在研究中，但迫切需要更多的研究来确定有效的疫苗或更安全的化疗药物，包括表观遗传药物，以科普这种病毒爆发，并开发针对COVID-19的暴露前和暴露后预防措施。
Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can regulate gene expression through a series of reversible epigenetic modifications, such as histone methylation and acetylation, DNA/RNA methylation, chromatin remodeling, and non-coding RNAs. The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, and spread worldwide, causes it. COVID-19 severity and consequences largely depend on patient age and health status. In this review, we will summarize and comparatively analyze how viruses regulate the host epigenome. Mainly, we will be focusing on highly pathogenic respiratory RNA virus infections such as coronaviruses. In this context, epigenetic alterations might play an essential role in the onset of coronavirus disease complications. Although many therapeutic approaches are under study, more research is urgently needed to identify effective vaccine or safer chemotherapeutic drugs, including epigenetic drugs, to cope with this viral outbreak and to develop pre- and post-exposure prophylaxis against COVID-19.
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影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali
DOI：
10.1084/jem.20112343
发表时间：
2012-04-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fang TC;Schaefer U;Mecklenbrauker I;Stienen A;Dewell S;Chen MS;Rioja I;Parravicini V;Prinjha RK;Chandwani R;MacDonald MR;Lee K;Rice CM;Tarakhovsky A
通讯作者：
Tarakhovsky A
影响因子：
64.5
作者：
Goldberg, Aaron D.;Allis, C. David;Bernstein, Emily
通讯作者：
Bernstein, Emily
影响因子：
7.3
作者：
Geller, Anne;Yan, Jun
通讯作者：
Yan, Jun
影响因子：
64.8
作者：
Gordon, David E.;Jang, Gwendolyn M.;Krogan, Nevan J.
通讯作者：
Krogan, Nevan J.