Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T.
Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T.
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DOI：
10.1177/1352458510384010
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Lynch SG
中科院分区：
文献类型：
--
作者：
Choi IY;Lee SP;Denney DR;Lynch SG
尽管MRI T2病变负荷稳定，但继发性进行性多发性硬化（SPMS）患者的残疾水平通常会恶化。在没有可测量的炎症的情况下存在氧化应激可能有助于解释这种现象。在这项研究中，在体内的氧化应激，脑谷胱甘肽（GSH），使用磁共振化学位移成像（CSI）的评估进行了描述，并与SPMS患者和健康对照组的GSH水平进行了比较。评估与匹配的对照组相比，SPMS患者的GSH（大脑中的关键抗氧化剂）是否较低。研究了17例SPMS患者（扩展残疾状态量表= 4.0-7.0; MS诊断时间= 19.4±7年）和17名年龄和性别匹配的健康对照。使用专门设计的磁共振波谱技术，在3 T下测量脑额顶叶区域的GSH水平。SPMS患者的GSH水平低于对照组，最大的下降幅度（18.5%）在额叶区域（p=0.001）。这些患者中较低的GSH水平表明SPMS中存在氧化应激。这一过程可能至少部分地导致SPMS功能持续下降。
Disability levels for patients with secondary progressive multiple sclerosis (SPMS) often worsen despite a stable MRI T2 lesion burden. The presence of oxidative stress in the absence of measurable inflammation could help explain this phenomenon. In this study, the assessment of an in vivo marker of oxidative stress, cerebral glutathione (GSH), using magnetic resonance chemical shift imaging (CSI) is described, and GSH levels were compared in patients with SPMS and healthy controls. To assess whether GSH, a key antioxidant in the brain, is lower in the SPMS patients compared to matched controls. Seventeen patients with SPMS (Expanded Disability Status Scale = 4.0–7.0; length of MS diagnosis = 19.4±7 years) and 17 age- and gender-matched healthy controls were studied. GSH levels were measured in the fronto-parietal regions of the brain using a specially designed magnetic resonance spectroscopy technique, CSI of GSH, at 3T. The levels of GSH were lower for SPMS patients than for controls, the largest reduction (18.5%) being in the frontal region (p=0.001). The lower GSH levels in these patients indicate the presence of oxidative stress in SPMS. This process could be at least partially responsible for ongoing functional decline in SPMS.
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影响因子：
3.7
作者：
Aboul-Enein F;Krssák M;Höftberger R;Prayer D;Kristoferitsch W
通讯作者：
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DOI：
10.1196/annals.1306.021
发表时间：
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期刊：
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影响因子：
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