Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood.
Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood.
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辅助生殖技术与从婴儿到成年早期的后代生长和肥胖的关联。
DOI：
10.1001/jamanetworkopen.2022.22106
复制
发表时间：
2022-07-01
影响因子：
13.8
通讯作者：
Lawlor, Deborah A.
中科院分区：
文献类型：
--
作者：
Elhakeem, Ahmed;Taylor, Amy E.;Inskip, Hazel M.;Huang, Jonathan;Tafflet, Muriel;Vinther, Johan L.;Asta, Federica;Erkamp, Jan S.;Gagliardi, Luigi;Guerlich, Kathrin;Halliday, Jane;Harskamp-van Ginkel, Margreet W.;He, Jian-Rong;Jaddoe, Vincent W. V.;Lewis, Sharon;Maher, Gillian M.;Manios, Yannis;Mansell, Toby;McCarthy, Fergus P.;McDonald, Sheila W.;Medda, Emanuela;Nistico, Lorenza;de Moira, Angela Pinot;Popovic, Maja;Reiss, Irwin K. M.;Rodrigues, Carina;Salika, Theodosia;Smith, Ash;Stazi, Maria A.;Walker, Caroline;Wu, Muci;Asvold, Bjorn O.;Barros, Henrique;Brescianini, Sonia;Burgner, David;Chan, Jerry K. Y.;Charles, Marie-Aline;Eriksson, Johan G.;Gaillard, Romy;Grote, Veit;Haberg, Siri E.;Heude, Barbara;Koletzko, Berthold;Morton, Susan;Moschonis, George;Murray, Deirdre;O'Mahony, Desmond;Porta, Daniela;Qiu, Xiu;Richiardi, Lorenzo;Rusconi, Franca;Saffery, Richard;Tough, Suzanne C.;Vrijkotte, Tanja G. M.;Nelson, Scott M.;Andersen, Anne-Marie Nybo;Magnus, Maria C.;Lawlor, Deborah A.
辅助生殖技术受孕与婴儿期至成年早期的生长和肥胖相关吗？在这项队列研究中，来自欧洲、亚太地区和加拿大的多达158066名婴儿、儿童、青少年和年轻人，（体外受精或卵胞浆内单精子注射，加上胚胎移植）从婴儿期到青春期早期，与自然受孕的同龄人相比，大多数人都更矮，更轻，更瘦;然而，所有年龄组的差异都很小，并且随着年龄的增长而减少，95% CI有时包括零。这些发现表明，通过辅助生殖技术怀孕或希望怀孕的父母及其后代应该放心，早期生命生长和肥胖的差异很小，到青春期后期不再明显。这项队列研究调查了欧洲，亚太地区和北美26个基于人群的队列中，从婴儿期到成年早期，辅助生殖技术与后代生长和肥胖的相关性。使用辅助生殖技术（ART）受孕的人占世界人口的比例越来越大。在一项大型多队列研究中调查ART受孕与婴儿期至成年早期后代生长和肥胖的关系。这项队列研究使用了26项欧洲，亚太和北美基于人群的队列研究的预先指定的协调分析，其中包括1984年至2018年出生的人，评估生长和肥胖结果的平均年龄为0.6个月至27.4岁。分析了2019年11月至2022年2月期间的数据。ART受孕（主要是体外受精，卵胞浆内单精子注射和胚胎移植）与自然受孕（NC;没有任何医学辅助生殖）。主要结果是身高/身高、体重和体重指数（BMI;计算方法为体重（kg）除以身高（m）的平方）。对每个队列分别进行分析，调整母亲BMI、年龄、吸烟、教育、产次、种族和后代性别和年龄。结果合并在13个年龄组的随机效应荟萃分析中。每个年龄组的荟萃分析包括多达158066名后代（4329名通过ART受孕），每个队列中女性占47.6%至60.6%。与NC的后代相比，通过ART受孕的后代从婴儿期到青春期早期更短，更轻，更瘦，最小年龄的差异最大，随着年龄的增长而减弱。例如，后代体重的校正平均差异为-0.27（95% CI，−0.39至−0.16）小于3个月时的SD单位，−0.16（95% CI，−0.22至−0.09）17至23月龄时的SD单位，−0.07（95% CI，−0.10至−0.04）SD单位（6至9岁）和−0.02（95% CI，−0.15至0.12）SD单位（14至17岁）。与NC相比，较小的后代尺寸仅限于通过新鲜但非冷冻胚胎移植受孕的个体（例如，新鲜胚胎移植与NC在4至5岁时的体重差异为-0.14 [95% CI，-0.20至0.07] SD单位，冷冻胚胎移植与NC为0.00 [95% CI，-0.15至0.15] SD单位）。在体脂测量中观察到更显著的差异，并且有不精确的证据表明，ART受孕的后代在成年早期出现了更大的肥胖（例如，ART与NC在17岁以上的脂肪质量指数差异：0.23 [95% CI，-0.04至0.50] SD单位）。这些发现表明，通过ART受孕或受孕的人可以放心，早期生长和肥胖的差异很小，到青春期后期不再明显。
Is conception by assisted reproductive technology associated with growth and adiposity from infancy to early adulthood? In this cohort study of up to 158 066 infants, children, adolescents and young adults from Europe, Asia-Pacific, and Canada, those conceived using assisted reproductive technology (in vitro fertilization or intracytoplasmic sperm injection, plus embryo transfers) were shorter, lighter, and thinner by most estimates from infancy up to early adolescence compared with their naturally conceived peers; however, the differences were small across all ages and reduced with older age, with 95% CIs sometimes including the null. These findings suggest that parents conceiving or hoping to conceive through assisted reproductive technology and their offspring should be reassured that differences in early life growth and adiposity are small and no longer apparent by late adolescence. This cohort study investigates the association of conception with assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood across 26 population-based cohorts in Europe, Asia-Pacific, and North America. People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world’s population. To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study. This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022. Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction). The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups. Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were −0.27 (95% CI, −0.39 to −0.16) SD units at age younger than 3 months, −0.16 (95% CI, −0.22 to −0.09) SD units at age 17 to 23 months, −0.07 (95% CI, −0.10 to −0.04) SD units at age 6 to 9 years, and −0.02 (95% CI, −0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was −0.14 [95% CI, −0.20 to −0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, −0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, −0.04 to 0.50] SD units). These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.
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影响因子：
120.7
作者：
Carson, Sandra Ann;Kallen, Amanda N.
通讯作者：
Kallen, Amanda N.
影响因子：
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作者：
Hann M;Roberts SA;D'Souza SW;Clayton P;Macklon N;Brison DR
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影响因子：
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作者：
Monteiro, POA;Victora, CG
通讯作者：
Victora, CG
影响因子：
13.6
作者：
Pinot de Moira A;Haakma S;Strandberg-Larsen K;van Enckevort E;Kooijman M;Cadman T;Cardol M;Corpeleijn E;Crozier S;Duijts L;Elhakeem A;Eriksson JG;Felix JF;Fernández-Barrés S;Foong RE;Forhan A;Grote V;Guerlich K;Heude B;Huang RC;Järvelin MR;Jørgensen AC;Mikkola TM;Nader JLT;Pedersen M;Popovic M;Rautio N;Richiardi L;Ronkainen J;Roumeliotaki T;Salika T;Sebert S;Vinther JL;Voerman E;Vrijheid M;Wright J;Yang TC;Zariouh F;Charles MA;Inskip H;Jaddoe VWV;Swertz MA;Nybo Andersen AM;LifeCycle Project Group
通讯作者：
LifeCycle Project Group
DOI：
10.1001/jama.2015.17296
发表时间：
2015-12-22
期刊：
JAMA
影响因子：
--
作者：
Smith ADAC;Tilling K;Nelson SM;Lawlor DA
通讯作者：
Lawlor DA