11 Carbonic Anhydrases in Fungi and Fungal-Like Organisms – Functional Distribution and Evolution of a Gene Family

11 Carbonic Anhydrases in Fungi and Fungal-Like Organisms – Functional Distribution and Evolution of a Gene Family
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真菌和类真菌生物中的 11 种碳酸酐酶——基因家族的功能分布和进化

DOI:
10.1007/978-3-642-19974-5_11
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发表时间:
2011
影响因子:
9.3
通讯作者:
Skander Elleuche
Skander Elleuche
中科院分区:
医学1区
文献类型:
--
作者:
Skander Elleuche

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碳酸酐酶基因家族由能够快速加速从二氧化碳到碳酸氢盐的自发和可逆相互转化的酶组成。迄今为止,真菌碳酸酐酶已在一些“基础真菌”、子囊菌、担子菌以及真菌学家研究的所谓非真菌生物体的基因组中被发现。根据碳酸酐酶的一级结构,它们被分为五个不相关的进化类别(α、β、γ、δ、z)。所有研究的真菌中都存在至少一种单一的 β 类碳酸酐酶,而 δ 和 δ 家族的成员尚未在真菌和类真菌生物中被发现。显然多次发生的重复事件似乎是该基因家族进化史上的主要力量,并且可能反映了许多特化事件。
The gene family of carbonic anhydrases consists of enzymes that are capable to rapidly accelerate the spontaneous and reversible interconversion from carbon dioxide to bicarbonate. To date, fungal carbonic anhydrases have been identified in the genomes of some ‘basal fungi’, ascomycetes, basidiomycetes and also within the so-called group of non-fungal organisms studied by mycologists. Based on the primary structure of carbonic anhydrases, they have been separated in five unrelated evolutionary classes (α, β, γ, δ, ζ). At least one single β-class carbonic anhydrase is present in all fungi investigated, while members of the δ- and ζ-families have not been identified in fungi and fungal-like organisms. Duplication events, which have obviously occurred at several times, seem to be the major force in the evolutionary history of this gene family and might reflect numerous specialization events.
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发表时间: 2010-04-08
期刊: PLoS genetics
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