ADMA: A Key Player in the Relationship between Vascular Dysfunction and Inflammation in Atherosclerosis.
ADMA: A Key Player in the Relationship between Vascular Dysfunction and Inflammation in Atherosclerosis.
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DOI：
10.3390/jcm9093026
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发表时间：
2020-09-20
影响因子：
3.9
通讯作者：
Leiper J
中科院分区：
文献类型：
--
作者：
Dowsett L;Higgins E;Alanazi S;Alshuwayer NA;Leiper FC;Leiper J
动脉粥样硬化是一种慢性心血管疾病，可增加心肌梗死和中风等主要心血管事件的风险。不对称二甲基精氨酸（ADMA）血浆浓度升高长期以来被认为是心血管疾病的标志，并与心血管风险因素（包括高血压、肥胖和高血脂）相关。在这篇综述中，我们讨论了ADMA浓度与动脉粥样硬化发展风险增加相关的临床文献。动脉粥样硬化病变的形成依赖于血管功能障碍之间的相互作用，导致内皮活化和炎性细胞，特别是巨噬细胞，在血管壁内的积累。在这里，我们审查的机制，通过升高ADMA有助于内皮功能障碍，激活和活性氧（ROS）的生产; ADMA如何可能影响血管平滑肌表型;最后ADMA是否在血管壁内发生的炎症过程中发挥调节作用。
Atherosclerosis is a chronic cardiovascular disease which increases risk of major cardiovascular events including myocardial infarction and stroke. Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) have long been recognised as a hallmark of cardiovascular disease and are associated with cardiovascular risk factors including hypertension, obesity and hypertriglyceridemia. In this review, we discuss the clinical literature that link ADMA concentrations to increased risk of the development of atherosclerosis. The formation of atherosclerotic lesions relies on the interplay between vascular dysfunction, leading to endothelial activation and the accumulation of inflammatory cells, particularly macrophages, within the vessel wall. Here, we review the mechanisms through which elevated ADMA contributes to endothelial dysfunction, activation and reactive oxygen species (ROS) production; how ADMA may affect vascular smooth muscle phenotype; and finally whether ADMA plays a regulatory role in the inflammatory processes occurring within the vessel wall.
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影响因子：
3.9
作者：
Arlouskaya, Yana;Sawicka, Ada;Wrzosek, Malgorzata
通讯作者：
Wrzosek, Malgorzata
DOI：
10.1016/s0735-1097(00)01013-5
发表时间：
2000-12-01
影响因子：
24
作者：
Böger, RH;Bode-Böger, SM;Cooke, JP
通讯作者：
Cooke, JP
影响因子：
5.4
作者：
Ajtay, Zeno;Scalera, Fortunato;Bode-Boeger, Stefanie M.
通讯作者：
Bode-Boeger, Stefanie M.
影响因子：
8.3
作者：
Antoniades, Charalambos;Demosthenous, Michael;Stefanadis, Christodoulos
通讯作者：
Stefanadis, Christodoulos
影响因子：
5.8
作者：
Altinova, Alev E.;Arslan, Metin;Toruner, Fusun B.
通讯作者：
Toruner, Fusun B.