The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
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亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与中国西南地区乳腺癌亚型易感性相关
DOI：
10.1371/journal.pone.0254267
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Li Z;Zhang J;Zou W;Xu Q;Li S;Wu J;Zhu L;Zhang Y;Xu L;Zhang Y;Luo Q;Nie J;Li X;Zou T;Chen C
据报道，亚甲基四氢叶酸还原酶（MTHFR）是一种叶酸依赖性酶，与多种癌症类型有关。 MTHFR C677T 多态性影响许多生物过程，包括肿瘤发生。然而，MTHFR C677T 多态性与乳腺癌 (BC) 亚型之间的关联尚不完全清楚。在本研究中，对来自中国西南地区的 490 名患有或不患有 BC 的个体进行了 MTHFR C677T 多态性的基因分型。 MTHFR C677T 多态性与 BC 的关联性分析显示，MTHFR C677T 多态性与三阴性乳腺癌（TNBC）之间存在显着相关性（OR = 2.83，95% CI：1.12~9.51，P = 0.0401）。此外，MTHFR C677T 多态性还可以作为 luminal A 型乳腺癌的保护因子（OR = 0.57，95% CI：0.34–0.94，P = 0.0258）。 MTHFR C677T 多态性与临床特征之间关联的评估表明，患有高血压的人患 BC 的风险增加（OR = 2.27；95% CI：1.08-4.6；P = 0.0264），特别是 TNBC（OR = 215.38；95% CI：2.45-84430.3；P = 0.0317）。我们的结果表明 MTHFR C677T 多态性与腔 B 型乳腺癌和 TNBC 的易感性显着相关。
Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) subtypes is not fully understood. In this study, the MTHFR C677T polymorphism was genotyped in 490 individuals with or without BC from southwestern China. Analysis of the association between the MTHFR C677T polymorphism and BC revealed that there was a significant association between the MTHFR C677T polymorphism and triple-negative breast cancer (TNBC) (OR = 2.83, 95% CI: 1.12–9.51, P = 0.0401). Furthermore, the MTHFR C677T polymorphism can also serve as a protective factor in luminal A breast cancer (OR = 0.57, 95% CI: 0.34–0.94, P = 0.0258). Evaluation of the association between the MTHFR C677T polymorphism and clinical characteristics indicated that people who suffered from hypertension had an increased risk for BC (OR = 2.27; 95% CI: 1.08–4.6; P = 0.0264), especially TNBC (OR = 215.38; 95% CI: 2.45–84430.3; P = 0.0317). Our results suggest that the MTHFR C677T polymorphism is significantly associated with susceptibility to luminal B breast cancer and TNBC.
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影响因子：
3.8
作者：
De Ocampo, Maria P. G.;Araneta, Maria Rosario G.;Chambers, Christina D.
通讯作者：
Chambers, Christina D.
DOI：
10.1073/pnas.062066299
发表时间：
2002-04-16
影响因子：
11.1
作者：
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影响因子：
168.9
作者：
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通讯作者：
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影响因子：
4.4
作者：
Chmurzynska, Agata;Malinowska, Anna M.;Gawecki, Jan
通讯作者：
Gawecki, Jan
DOI：
10.1200/jco.2017.74.0472
发表时间：
2017-08-20
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Krop I;Ismaila N;Andre F;Bast RC;Barlow W;Collyar DE;Hammond ME;Kuderer NM;Liu MC;Mennel RG;Van Poznak C;Wolff AC;Stearns V
通讯作者：
Stearns V