Obesity and weight change in relation to breast cancer survival.
Obesity and weight change in relation to breast cancer survival.
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DOI：
10.1007/s10549-009-0708-3
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发表时间：
2010-08
影响因子：
3.8
通讯作者：
Shu, Xiao Ou
中科院分区：
文献类型：
--
作者：
Chen, Xiaoli;Lu, Wei;Zheng, Wei;Gu, Kai;Chen, Zhi;Zheng, Ying;Shu, Xiao Ou
作者评估了乳腺癌诊断后肥胖和体重变化对预后的影响。在2002年至2006年期间，共有5042名年龄在20-75岁的乳腺癌患者在确诊后大约6个月通过上海癌症登记中心被确定为乳腺癌患者，并纳入研究。参与者随后进行面谈，并与上海生命统计登记处数据库建立记录联系。进行了人体测量，并通过面对面访谈收集了有关社会人口、临床和生活方式因素的信息。在46个月的中位随访期间，记录了442例死亡和534例复发/乳腺癌相关死亡。确诊时体重指数≥为30的女性的死亡率高于体重指数为18.5≤的女性；多变量调整后的风险比(HR)对于总死亡率为1.55(95%可信区间(95%CI)：1.10-2.17)，对于复发/疾病特定死亡率为1.44(95%CI：1.02-2.03)。在诊断前和诊断后的肥胖中也发现了类似的结果。≥增加5公斤或减去1公斤的女性的死亡率高于保持体重的女性。没有观察到腰臀比和死亡率之间的联系。我们的研究表明，诊断后肥胖和体重变化与乳腺癌预后呈负相关。体重控制对患有乳腺癌的女性来说很重要。
The authors evaluated the prognostic effects of obesity and weight change after breast cancer diagnosis. A total of 5042 breast cancer patients aged 20–75 were identified through the population-based Shanghai Cancer Registry approximately 6 months after cancer diagnosis and recruited into the study between 2002 and 2006. Participants were followed by in-person interviews supplemented by record linkage with the Shanghai Vital Statistics Registry database. Anthropometric measurements were taken and information on sociodemographic, clinical, and lifestyle factors was collected through in-person interviews. During the median follow-up of 46 months, 442 deaths and 534 relapses/breast cancer-specific deaths were documented. Women with body mass index (BMI) ≥30 at diagnosis had higher mortality than women with 18.5≤BMI<25; the multivariate adjusted hazard ratios (HRs) were 1.55 (95% confidence interval (95% CI): 1.10–2.17) for total mortality and 1.44 (95% CI: 1.02–2.03) for relapse/disease-specific mortality. Similar results were found for pre- and post-diagnostic obesity. Women who gained ≥5kg or lost >1kg had higher mortality than those who maintained their weight. No association was observed between waist-to-hip ratio and mortality. Our study suggests that obesity and weight change after diagnosis are inversely associated with breast cancer prognosis. Weight control is important among women with breast cancer.
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影响因子：
6.4
作者：
Dal Maso, Luigino;Zucchetto, Antonella;Franceschi, Silvia
通讯作者：
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影响因子：
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作者：
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通讯作者：
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