Adiponectin in anorexia nervosa and bulimia nervosa.
Adiponectin in anorexia nervosa and bulimia nervosa.
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脂联素在神经性厌食症和神经性贪食症中的作用。
DOI：
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发表时间：
2004
影响因子：
5.8
通讯作者：
Hideshi Kuzuya
中科院分区：
文献类型：
--
作者：
Tetsuya Tagami;Noriko Satoh;Takeshi Usui;Kazunori Yamada;Akira Shimatsu;Hideshi Kuzuya
为了研究脂联素（一种新的脂肪细胞特异性分泌蛋白）在进食障碍病理生理学中的作用，测定了31例神经性厌食症（AN）和11例神经性贪食症女性患者的空腹脂联素、瘦素、胰岛素和葡萄糖的循环水平。激素水平与16名年龄匹配的正常体重对照组，6名健康体质较瘦的受试者和9名肥胖受试者进行了比较。此外，13例AN患者在营养治疗和体重增加后重新评估了水平的变化。AN和神经性贪食症患者的血清脂联素浓度显著低于正常体重对照组。这些结果是出乎意料的，因为该水平在体质较瘦的受试者中较高而在肥胖受试者中较低，这提供了与体重指数（BMI）和体脂量的负相关性。相反，血清瘦素水平与所有患者和对照组的BMI和脂肪量相关性很好。AN患者的胰岛素抵抗明显较低，肥胖患者的胰岛素抵抗明显较高。体重恢复后的脂联素浓度增加到正常水平，尽管BMI增加相对较小。提示进食障碍患者的异常进食行为可降低循环脂联素水平，体重恢复可使其恢复。
To study the role of adiponectin, a novel adipocyte-specific secreted protein, on the pathophysiology of eating disorders, circulating levels of fasting adiponectin, leptin, insulin, and glucose were measured in 31 female patients with anorexia nervosa (AN) and in 11 with bulimia nervosa. Hormone levels were compared with 16 age-matched, normal body weight controls, six healthy constitutionally thin subjects, and nine obese subjects. Moreover, changes in levels were reevaluated after nutritional treatment and weight gain in 13 patients with AN. Serum adiponectin concentrations in AN and bulimia nervosa were significantly lower than those in normal-weight controls. These results were unexpected because the levels were high in constitutionally thin subjects and low in obese subjects, which provide a negative correlation with body mass index (BMI) and body fat mass. In contrast, serum leptin levels correlated very well with BMI and fat mass among all the patients and controls. The insulin resistance was significantly low in AN and high in obese subjects. The concentrations of adiponectin after weight recovery increased to the normal level despite a relatively small increase in BMI. These findings suggest that abnormal feeding behavior in the patients with eating disorders may reduce circulating adiponectin level, and weight recovery can restore it.
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神经性厌食症中的脑脊液瘦素：与营养状况的相关性和抵抗体重增加的潜在作用。
DOI：
10.1210/jcem.82.6.4006
发表时间：
1997
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Mantzoros,C;Flier,JS;Lesem,MD;Brewerton,TD;Jimerson,DC
通讯作者：
Jimerson,DC
影响因子：
15.9
作者：
Combs, TP;Berg, AH;Rossetti, L
通讯作者：
Rossetti, L
影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF