A linguistically informed autosomal STR survey of human populations residing in the greater Himalayan region.
A linguistically informed autosomal STR survey of human populations residing in the greater Himalayan region.
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DOI：
10.1371/journal.pone.0091534
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
de Knijff P
中科院分区：
文献类型：
--
作者：
Kraaijenbrink T;van der Gaag KJ;Zuniga SB;Xue Y;Carvalho-Silva DR;Tyler-Smith C;Jobling MA;Parkin EJ;Su B;Shi H;Xiao CJ;Tang WR;Kashyap VK;Trivedi R;Sitalaximi T;Banerjee J;Karma Tshering of Gaselô;Tuladhar NM;Opgenort JR;van Driem GL;Barbujani G;de Knijff P
大喜马拉雅地区划分了亚洲两个最重要的语言门：藏缅语和印欧语。以前的遗传调查，主要是使用Y染色体多态性和/或线粒体DNA多态性表明，属于这两个门的人口之间的基因流大大减少。然而，这些研究主要集中在居住在该山脉北部和/或南部的人群，并且还没有能够研究大喜马拉雅地区本身的基因流模式。我们现在报告一个详细的，语言学上知情的，遗传调查的藏缅语和印欧语的喜马拉雅国家尼泊尔和不丹的基础上常染色体微卫星标记，并比较这些人口与周边地区。喜马拉雅山脉内种群之间的遗传分化似乎比邻国种群之间的遗传分化要高得多。我们还观察到一个显着的遗传分化之间的藏缅语人口一方面和印欧语人口的另一方面，这表明语言和地理发挥了同样大的作用，在喜马拉雅山脉内的现代人口的遗传组成的定义。
The greater Himalayan region demarcates two of the most prominent linguistic phyla in Asia: Tibeto-Burman and Indo-European. Previous genetic surveys, mainly using Y-chromosome polymorphisms and/or mitochondrial DNA polymorphisms suggested a substantially reduced geneflow between populations belonging to these two phyla. These studies, however, have mainly focussed on populations residing far to the north and/or south of this mountain range, and have not been able to study geneflow patterns within the greater Himalayan region itself. We now report a detailed, linguistically informed, genetic survey of Tibeto-Burman and Indo-European speakers from the Himalayan countries Nepal and Bhutan based on autosomal microsatellite markers and compare these populations with surrounding regions. The genetic differentiation between populations within the Himalayas seems to be much higher than between populations in the neighbouring countries. We also observe a remarkable genetic differentiation between the Tibeto-Burman speaking populations on the one hand and Indo-European speaking populations on the other, suggesting that language and geography have played an equally large role in defining the genetic composition of present-day populations within the Himalayas.
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