A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats.
A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats.
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DOI：
10.1038/srep37278
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发表时间：
2016-11-17
影响因子：
4.6
通讯作者：
Herzog W
中科院分区：
文献类型：
--
作者：
Collins KH;Paul HA;Hart DA;Reimer RA;Smith IC;Rios JL;Seerattan RA;Herzog W
已知与肥胖相关的慢性低水平炎症会有害地影响肌肉组成。然而，肥胖导致肌肉损失的方式尚未在短期代谢挑战后详细或以综合方式进行探索。在本文中，我们评估了受损的肌肉完整性，饮食，全身炎症介质，脂肪组织和肠道微生物群之间的关系，在雄性Sprague-Dawley大鼠。我们发现，与对照饮食动物相比，肌内脂肪，纤维化和促炎细胞的数量增加了3天，并持续了28天的高脂肪高糖喂养。为了了解肌肉损伤的全身性因素，评价了肠道微生物群和血清炎症标志物的动态变化。这项研究的数据将代谢挑战与短短3天后肌肉完整性的持续损害联系起来，这一发现与肠道微生物群的改变和全身炎症变化有关。这些数据有助于我们了解代谢挑战对多个宿主系统的早期后果，这对于了解肥胖治疗方案的发展非常重要。因此，在代谢挑战的早期阶段进行干预可能对减轻肌肉完整性的持续变化至关重要。
The chronic low-level inflammation associated with obesity is known to deleteriously affect muscle composition. However, the manner in which obesity leads to muscle loss has not been explored in detail or in an integrated manner following a short-term metabolic challenge. In this paper, we evaluated the relationships between compromised muscle integrity, diet, systemic inflammatory mediators, adipose tissue, and gut microbiota in male Sprague-Dawley rats. We show that intramuscular fat, fibrosis, and the number of pro-inflammatory cells increased by 3-days and was sustained across 28-days of high-fat high-sugar feeding compared to control-diet animals. To understand systemic contributors to muscle damage, dynamic changes in gut microbiota and serum inflammatory markers were evaluated. Data from this study links metabolic challenge to persistent compromise in muscle integrity after just 3-days, a finding associated with altered gut microbiota and systemic inflammatory changes. These data contribute to our understanding of early consequences of metabolic challenge on multiple host systems, which are important to understand as obesity treatment options are developed. Therefore, intervention within this early period of metabolic challenge may be critical to mitigate these sustained alterations in muscle integrity.
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DOI：
10.1097/mco.0b013e328312c37d
发表时间：
2008-11
影响因子：
3.1
作者：
Stenholm S;Harris TB;Rantanen T;Visser M;Kritchevsky SB;Ferrucci L
通讯作者：
Ferrucci L
影响因子：
2.8
作者：
Collins, Kelsey H.;Hart, David A.;Herzog, Walter
通讯作者：
Herzog, Walter
影响因子：
4.2
作者：
Chicco, A;D'Alessandro, ME;Lombardo, YB
通讯作者：
Lombardo, YB
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
7.8
作者：
Tardif N;Salles J;Guillet C;Tordjman J;Reggio S;Landrier JF;Giraudet C;Patrac V;Bertrand-Michel J;Migne C;Collin ML;Chardigny JM;Boirie Y;Walrand S
通讯作者：
Walrand S