Age and Smoking Predict Antibody Titres at 3 Months after the Second Dose of the BNT162b2 COVID-19 Vaccine.
Age and Smoking Predict Antibody Titres at 3 Months after the Second Dose of the BNT162b2 COVID-19 Vaccine.
复制标题
DOI：
10.3390/vaccines9091042
复制
发表时间：
2021-09-18
期刊：
影响因子：
7.8
通讯作者：
Sugiyama K
中科院分区：
文献类型：
--
作者：
Nomura Y;Sawahata M;Nakamura Y;Kurihara M;Koike R;Katsube O;Hagiwara K;Niho S;Masuda N;Tanaka T;Sugiyama K
目的：我们的目的是确定第二剂 BNT162b2 2019 冠状病毒病 (COVID-19) 疫苗后 3 个月的抗体 (Ab) 滴度，并探索在日本预测这些滴度的临床变量。方法：我们招募了 378 名医护人员（255 名女性，123 名男性），他们在间隔 3 周两次接种 BNT162b2 COVID-19 mRNA 疫苗（辉瑞/BioNTech）中的第二次后 91 ± 15 天收集了血液样本。使用结构化的自我报告问卷记录病史和人口特征。分析了抗体滴度与这些因素之间的关系。结果：参与者的中位年龄（四分位距 (IQR)）为 44 (32–54) 岁。针对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 刺突抗原的中值抗体滴度 (IQR) 为 764 (423–1140) U/mL。年龄较大的参与者的抗体滴度明显较低； 20多岁男性和女性的中位（IQR）抗体滴度分别为942（675-1390）和1095（741-1613）U/mL，而60-70多岁男性和女性分别为490（297-571）和519（285-761）U/mL。在年龄调整分析中，抗体滴度较低的唯一危险因素是男性和吸烟。然而，性别差异可能是由吸烟率的性别差异引起的。此外，当前吸烟者的抗体滴度显着低于戒烟者。结论：与低抗体滴度相关的最重要因素是年龄和吸烟习惯。特别是，当前的吸烟状况导致抗体滴度较低，接种疫苗前戒烟可能会提高 BNT162b2 疫苗的个体疗效。
Objective: We aimed to determine antibody (Ab) titres 3 months after the second dose of the BNT162b2 coronavirus disease-2019 (COVID-19) vaccine and to explore clinical variables predicting these titres in Japan. Methods: We enrolled 378 healthcare workers (255 women, 123 men) whose blood samples were collected 91 ± 15 days after the second of two inoculations of the BNT162b2 COVID-19 mRNA vaccine (Pfizer/BioNTech) given 3 weeks apart. Medical histories and demographic characteristics were recorded using a structured self-reported questionnaire. The relationships between Ab titres and these factors were analysed. Results: Median age (interquartile range (IQR)) of the participants was 44 (32–54) years. Median Ab titre (IQR) against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antigen was 764 (423–1140) U/mL. Older participants had significantly lower Ab titres; median (IQR) Ab titres were 942 (675–1390) and 1095 (741–1613) U/mL in men and women in their 20s, respectively, but 490 (297–571) and 519 (285–761) U/mL in men and women in their 60–70s, respectively. In the age-adjusted analysis, the only risk factors for lower Ab titres were male sex and smoking. However, the sex difference may have arisen from the sex difference in smoking rate. Moreover, Ab titres were significantly lower in current smokers than in ex-smokers. Conclusions: The most important factors associated with low Ab titres were age and smoking habit. In particular, current smoking status caused lower Ab titres, and smoking cessation before vaccination may improve the individual efficacy of the BNT162b2 vaccine.
登录
查看更多内容
DOI：
10.1056/nejmoa2034545
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
通讯作者：
Oxford University Hospitals Staff Testing Group
影响因子：
64.8
作者：
Collier DA;Ferreira IATM;Kotagiri P;Datir RP;Lim EY;Touizer E;Meng B;Abdullahi A;CITIID-NIHR BioResource COVID-19 Collaboration;Elmer A;Kingston N;Graves B;Le Gresley E;Caputo D;Bergamaschi L;Smith KGC;Bradley JR;Ceron-Gutierrez L;Cortes-Acevedo P;Barcenas-Morales G;Linterman MA;McCoy LE;Davis C;Thomson E;Lyons PA;McKinney E;Doffinger R;Wills M;Gupta RK
通讯作者：
Gupta RK
影响因子：
28.3
作者：
Wei J;Stoesser N;Matthews PC;Ayoubkhani D;Studley R;Bell I;Bell JI;Newton JN;Farrar J;Diamond I;Rourke E;Howarth A;Marsden BD;Hoosdally S;Jones EY;Stuart DI;Crook DW;Peto TEA;Pouwels KB;Eyre DW;Walker AS;COVID-19 Infection Survey team
通讯作者：
COVID-19 Infection Survey team
DOI：
10.1056/nejmoa2108891
发表时间：
2021-08-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lopez Bernal J;Andrews N;Gower C;Gallagher E;Simmons R;Thelwall S;Stowe J;Tessier E;Groves N;Dabrera G;Myers R;Campbell CNJ;Amirthalingam G;Edmunds M;Zambon M;Brown KE;Hopkins S;Chand M;Ramsay M
通讯作者：
Ramsay M
影响因子：
--
作者：
MACKENZIE, JS;MACKENZIE, IH;HOLT, PG
通讯作者：
HOLT, PG