Phosphorus is associated with coronary artery disease in patients with preserved renal function.
Phosphorus is associated with coronary artery disease in patients with preserved renal function.
复制标题
磷与肾功能保留的患者的冠状动脉疾病有关。
DOI：
10.1371/journal.pone.0036883
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Moysés RM
中科院分区：
文献类型：
--
作者：
Cancela AL;Santos RD;Titan SM;Goldenstein PT;Rochitte CE;Lemos PA;dos Reis LM;Graciolli FG;Jorgetti V;Moysés RM
高血清磷水平与慢性肾病患者和普通人群的死亡率和心血管事件相关。此外，高磷水平已显示在体外诱导血管钙化和内皮功能障碍。本研究的目的是评价在肾功能正常的情况下磷与冠状动脉钙化和动脉粥样硬化的关系。这是一项横断面研究，涉及290例疑似冠状动脉疾病并接受择期冠状动脉造影的患者，肌酐清除率>60 ml/min/1.73 m2。冠状动脉阻塞通过Friesinger评分进行评估，冠状动脉钙化通过多层计算机断层扫描进行评估。Agatston评分>10的患者血清磷高于Agatston评分≤10的患者（3.63±0.55 vs 3.49±0.52 mg/dl; p = 0.02）。 在Friesinger评分>4的患者中，血清磷较高（3.6±0.5 vs 3.5±0.6 mg/dl，p = 0.04），完整成纤维细胞生长因子23中位数较低（40.3 pg/ml vs 45.7 pg/ml，p = 0.01）。 血清磷酸盐每升高0.1 mg/dl，Friesinger评分>4的几率增加7.4%（p = 0.03），Agatston评分>10的风险增加6.1%（p = 0.01）。 成纤维细胞生长因子23是Friesinger评分的阴性预测因子（p = 0.002）。 总之，在疑似冠状动脉疾病但肾功能正常的患者中，磷与冠状动脉钙化和阻塞呈正相关。
High serum phosphorus levels have been associated with mortality and cardiovascular events in patients with chronic kidney disease and in the general population. In addition, high phosphorus levels have been shown to induce vascular calcification and endothelial dysfunction in vitro. The aim of this study was to evaluate the relation of phosphorus and coronary calcification and atherosclerosis in the setting of normal renal function. This was a cross-sectional study involving 290 patients with suspected coronary artery disease and undergoing elective coronary angiography, with a creatinine clearance >60 ml/min/1.73 m2. Coronary artery obstruction was assessed by the Friesinger score and coronary artery calcification by multislice computed tomography. Serum phosphorus was higher in patients with an Agatston score >10 than in those with an Agatston score ≤10 (3.63±0.55 versus 3.49±0.52 mg/dl; p = 0.02). In the patients with Friesinger scores >4, serum phosphorus was higher (3.6±0.5 versus 3.5±0.6 mg/dl, p = 0.04) and median intact fibroblast growth factor 23 was lower (40.3 pg/ml versus 45.7 pg/ml, p = 0.01). Each 0.1-mg/dl higher serum phosphate was associated with a 7.4% higher odds of having a Friesinger score >4 (p = 0.03) and a 6.1% greater risk of having an Agatston score >10 (p = 0.01). Fibroblast growth factor 23 was a negative predictor of Friesinger score (p = 0.002). In conclusion, phosphorus is positively associated with coronary artery calcification and obstruction in patients with suspected coronary artery disease and preserved renal function.
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DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
5.3
作者：
Onufrak, Stephen J.;Bellasi, Antonio;Raggi, Paolo
通讯作者：
Raggi, Paolo
影响因子：
6.1
作者：
Mirza, Majd A. I.;Hansen, Tomas;Larsson, Tobias E.
通讯作者：
Larsson, Tobias E.
影响因子：
6.8
作者：
Rasouli, M;Kiasari, AM
通讯作者：
Kiasari, AM
影响因子：
39.2
作者：
Parker BD;Schurgers LJ;Brandenburg VM;Christenson RH;Vermeer C;Ketteler M;Shlipak MG;Whooley MA;Ix JH
通讯作者：
Ix JH