Respiratory viral infections after hematopoietic stem cell transplantation in children.
Respiratory viral infections after hematopoietic stem cell transplantation in children.
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DOI：
10.3346/jkms.2013.28.1.36
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发表时间：
2013-01
影响因子：
4.5
通讯作者：
Ahn HS
中科院分区：
文献类型：
--
作者：
Choi JH;Choi EH;Kang HJ;Park KD;Park SS;Shin HY;Lee HJ;Ahn HS
本研究旨在描述接受造血干细胞移植（HSCT）的儿科患者中呼吸道病毒感染的特征。研究样本包括从2007年至2010年在韩国首尔国立大学儿童医院进行的175个连续HSCT队列的116名儿童中发生的358次临床发作中获得的402份呼吸道标本。对鼻病毒、呼吸道合胞病毒（RSV）、副流感病毒（PIV）、腺病毒、人冠状病毒（hCoV）、流感病毒和人偏肺病毒进行多重逆转录聚合酶链反应。在58名患者中发生的89起临床事件中确定了病毒。在89例临床病例中，常见病毒为鼻病毒25例（28.1%），RSV 23例（25.8%），PIV-3 16例（18.0%），腺病毒12例（13.5%），hCoV 10例（11.2%）。下呼吸道感染34例（38.2%）。24次（27.0%）发作中出现中性粒细胞减少，31次（34.8%）发作中出现淋巴细胞减少。63%的临床发作是医院获得性的。3例患者死于呼吸道病毒感染引起的呼吸衰竭。在接受HSCT的儿科患者中，呼吸道病毒感染很常见，并且经常在住院期间获得。需要持续监测，以确定呼吸道病毒在免疫功能低下儿童中的作用以及预防策略的重要性。
This study was performed to characterize respiratory viral infections in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Study samples included 402 respiratory specimens obtained from 358 clinical episodes that occurred in the 116 children of the 175 consecutive HSCT cohort at Seoul National University Children's Hospital, Korea from 2007 to 2010. Multiplex reverse-transcription polymerase chain reactions were performed for rhinovirus, respiratory syncytial virus (RSV), parainfluenza viruses (PIVs), adenovirus, human coronavirus (hCoV), influenza viruses and human metapneumovirus. Viruses were identified in 89 clinical episodes that occurred in 58 patients. Among the 89 clinical episodes, frequently detected viruses were rhinovirus in 25 (28.1%), RSV in 23 (25.8%), PIV-3 in 16 (18.0%), adenovirus in 12 (13.5%), and hCoV in 10 (11.2%). Lower respiratory tract infections were diagnosed in 34 (38.2%). Neutropenia was present in 24 (27.0%) episodes and lymphopenia was in 31 (34.8%) episodes. Sixty-three percent of the clinical episodes were hospital-acquired. Three patients died of respiratory failure caused by respiratory viral infections. Respiratory viral infections in pediatric patients who have undergone HSCT are common and are frequently acquired during hospitalization. Continuous monitoring is required to determine the role of respiratory viruses in immunocompromised children and the importance of preventive strategies.
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影响因子：
4.4
作者：
Kumar D;Humar A
通讯作者：
Humar A
DOI：
10.1007/s10096-002-0864-4
发表时间：
2003-02-01
影响因子：
4.5
作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
Cordonnier, C
影响因子：
11.8
作者：
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通讯作者：
Sierra, J
影响因子：
20.3
作者：
Nichols, WG;Corey, L;Boeckh, M
通讯作者：
Boeckh, M