Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes.
Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes.
复制标题
DOI：
10.1016/j.atherosclerosis.2010.08.080
复制
发表时间：
2010-12
期刊：
影响因子：
5.3
通讯作者：
Orchard, Trevor J.
中科院分区：
文献类型：
--
作者：
Prince, Catherine T.;Secrest, Aaron M.;Mackey, Rachel H.;Arena, Vincent C.;Kingsley, Lawrence A.;Orchard, Trevor J.
关键词：
1 型糖尿病 (T1D) 与过早冠状动脉疾病 (CAD) 的高风险和死亡率相关，包括亚临床标志物冠状动脉钙化 (CAC) 和下肢动脉疾病 (LEAD)。脉搏波分析 (PWA) 动脉僵硬度指数与不同人群的心血管疾病 (CVD) 危险因素和结果相关，但对于 T1D 中的这些关系知之甚少。使用 Sphygmocor Px 设备对匹兹堡 EDC 儿童期 T1D 研究的 144 名参与者进行了 PWA。研究了动脉僵硬度指数、增强指数 (AIx) 和增强压 (AP) 以及心内膜下活力比 (SEVR)（心肌灌注的估计）与流行 CAD、电子束计算机断层扫描测量的 CAC 和低（<0.90）踝臂指数 (ABI) 之间的横截面关联。较高的 AP（但不是 AIx）和较低的 SEVR 与流行的 CAD、高 CAC 评分和低 ABI 单变量相关。然而，在调整年龄后，AP 和 SEVR 与 CAD 和 CAC 的关联并不仍然显着。在不使用硝酸盐的个体中，硝酸盐对 PWA 测量有很大影响，患有 CAD 事件的人的 AP 显着较高，并且比年龄或肱动脉血压测量更能解释差异。在多变量模型中，SEVR 与低 ABI 相关。在 1 型糖尿病中，较高的增压压力与 CAD 患病率以及 ABI 较低时估计的心肌灌注独立相关。因此，这些措施可能有助于更好地表征 1 型糖尿病的 CVD 风险，需要进行前瞻性检查。
Type 1 diabetes (T1D) is associated with a high risk for and mortality from premature coronary artery disease (CAD), including coronary artery calcification (CAC), a subclinical marker, and lower extremity arterial disease (LEAD). Pulse Wave Analysis (PWA) arterial stiffness indices have been associated with cardiovascular disease (CVD) risk factors and outcomes in various populations, but little is known regarding these relationships in T1D. PWA was performed using the Sphygmocor Px device on 144 participants in the Pittsburgh EDC Study of childhood onset T1D. The cross-sectional associations between arterial stiffness indices, augmentation index (AIx) and augmentation pressure (AP), and subendocardial viability ratio (SEVR), an estimate of myocardial perfusion, with prevalent CAD, electron beam computed tomography-measured CAC and low (<0.90) ankle-brachial index (ABI) were examined. Higher AP (but not AIx) and lower SEVR were univariately associated with prevalent CAD, high CAC score, and low ABI. AP and SEVR’s association with CAD and CAC did not, however, remain significant after adjustment for age. In individuals not using nitrates, which profoundly affect PWA measures, AP was significantly higher in those with CAD events and explained more of the variance than either age or brachial blood pressure measures. SEVR was associated with low ABI in multivariable models. Greater augmentation pressure is independently associated with prevalent CAD and estimated myocardial perfusion with low ABI in type 1 diabetes. These measures may thus help to better characterize CVD risk in type 1 diabetes and need to be examined prospectively.
登录
查看更多内容
DOI：
10.1046/j.1440-1681.2001.03570.x
发表时间：
2001-12-01
影响因子：
2.9
作者：
Pannier, BM;Guerin, AP;London, GM
通讯作者：
London, GM
影响因子：
8.7
作者：
Lloyd, CE;Kuller, LH;Orchard, TJ
通讯作者：
Orchard, TJ
影响因子：
2.8
作者：
Costacou, Tina;Edmundowicz, Daniel;Orchard, Trevor J.
通讯作者：
Orchard, Trevor J.
影响因子：
5.3
作者：
Khaleghi, Mahyar;Kullo, Iftikhar J.
通讯作者：
Kullo, Iftikhar J.
影响因子：
8
作者：
Altunkan, Sekip;Oztas, Kamuran;Seref, Besim
通讯作者：
Seref, Besim