Hyaluronidases in Human Diseases.
Hyaluronidases in Human Diseases.
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DOI：
10.3390/ijms22063204
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发表时间：
2021-03-22
影响因子：
5.6
通讯作者：
Keswani SG
中科院分区：
文献类型：
--
作者：
Kaul A;Short WD;Wang X;Keswani SG
近年来，随着对透明质酸(HA)研究的兴起，透明质酸酶(HYALs)在调节各种组织中HA的分解代谢及其分子量分布中的作用逐渐为人们所认识。在人类基因组中的六个类透明质酸酶基因序列中，HYAL1和HYAL2具有特别重要的意义，因为它们是人体组织中活跃的主要透明质酸酶。也许更重要的是，为了这篇综述，他们将抗炎和抗纤维化的高分子量HA切割成促炎和促纤维化的寡糖。在这种情况下，HYALs调节HA的降解，从而调节各种疾病的发生和发展。鉴于过去十年中缺乏专门关注HYALs的文献，本综述试图阐述它们在人类皮肤、心脏、肾脏等疾病中的作用。该综述将深入探讨HYALs的分子机制和途径，并讨论HYALs作为临床治疗的当前和潜在的未来疗效。
With the burgeoning interest in hyaluronic acid (HA) in recent years, hyaluronidases (HYALs) have come to light for their role in regulating catabolism of HA and its molecular weight (MW) distribution in various tissues. Of the six hyaluronidase-like gene sequences in the human genome, HYALs 1 and 2 are of particular significance because they are the primary hyaluronidases active in human somatic tissue. Perhaps more importantly, for the sake of this review, they cleave anti-inflammatory and anti-fibrotic high-molecular-weight HA into pro-inflammatory and pro-fibrotic oligosaccharides. With this, HYALs regulate HA degradation and thus the development and progression of various diseases. Given the dearth of literature focusing specifically on HYALs in the past decade, this review seeks to expound their role in human diseases of the skin, heart, kidneys, and more. The review will delve into the molecular mechanisms and pathways of HYALs and discuss current and potential future therapeutic benefits of HYALs as a clinical treatment.
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DOI：
10.1096/fj.201600856r
发表时间：
2017-03
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Balaji S;Wang X;King A;Le LD;Bhattacharya SS;Moles CM;Butte MJ;de Jesus Perez VA;Liechty KW;Wight TN;Crombleholme TM;Bollyky PL;Keswani SG
通讯作者：
Keswani SG
影响因子：
33.6
作者：
Jiang D;Liang J;Noble PW
通讯作者：
Noble PW
DOI：
10.1084/jem.50.3.327
发表时间：
1929-08-31
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Duran-Reynals F
通讯作者：
Duran-Reynals F
影响因子：
--
作者：
Chowdhury, Biswajit;Xiang, Bo;Triggs-Raine, Barbara
通讯作者：
Triggs-Raine, Barbara
影响因子：
4.8
作者：
Jadin, Laurence;Wu, Xiaoli;Flamion, Bruno
通讯作者：
Flamion, Bruno