Tissue-engineered product: allogeneic cultured dermal substitute composed of spongy collagen with fibroblasts.
Tissue-engineered product: allogeneic cultured dermal substitute composed of spongy collagen with fibroblasts.
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组织工程产品：由海绵状胶原蛋白和成纤维细胞组成的同种异体培养真皮替代品。
作者：
Y. Kuroyanagi;N. Yamada;Rie Yamashita;Eiju Uchinuma
近来，包括培养的表皮替代物（CES）、培养的真皮替代物（CDS）和培养的皮肤替代物（CSS）的各种类型的同种异体皮肤替代物已经被用作生物伤口敷料，所述同种异体皮肤替代物由作为细胞组分的角质形成细胞和/或成纤维细胞组成。在我们的研究中，通过将成纤维细胞铺在海绵状胶原上来制备同种异体CDS。使用新鲜或冷冻保存的同种异体CDS进行临床评价。在我们的145例临床病例中，95%（138/145）的各种伤口被评估为达到良好或优秀的结果，包括96%（22/23）的深度真皮烧伤（DDB）和真皮烧伤（DB），100%（53/53）部分厚度供体伤口，91%（21/23）创伤性皮肤缺损，压疮100%（5/5），慢性皮肤溃疡82%（9/11），清创DB覆盖率100%（6/6），自体网状移植物覆盖率92%（22/24）。我们的研究结果表明，同种异体CDS能够为部分和/或全层皮肤缺损患者提供有效的治疗。
Recently, various types of allogeneic skin substitutes including cultured epidermal substitute (CES), cultured dermal substitute (CDS), and cultured skin substitute (CSS), which are composed of keratinocytes and/or fibroblasts as the cellular component(s), have been used as biological wound dressings. In our study, the allogeneic CDS was prepared by plating fibroblasts on a spongy collagen. The clinical evaluation was conducted using fresh or cryopreserved allogeneic CDS. In 145 of our clinical cases, 95% (138/145) of various wounds were evaluated as achieving good or excellent results, including 96% (22/23) of deep dermal burns (DDB) and dermal burns (DB), 100% (53/53) of partial-thickness donor wounds, 91% (21/23) of traumatic skin defects, 100% (5/5) of pressure ulcers, 82% (9/11) of chronic skin ulcers, 100% (6/6) of coverage for debrided DB, and 92% (22/24) of coverage for autologous meshed graft. The results obtained in our study suggest that the allogeneic CDS is able to provide an effective therapy for patients with partial and/or full-thickness skin defects.
DOI：
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发表时间：
1989
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
C. Compton;J. M. Gill;D. Bradford;S. Regauer;G. Gallico;Nicholas E. O'Connor
通讯作者：
C. Compton;J. M. Gill;D. Bradford;S. Regauer;G. Gallico;Nicholas E. O'Connor
DOI：
10.1097/00004630-199311000-00010
发表时间：
1993-01-01
期刊：
Journal of Burn Care and Rehabilitation
影响因子：
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作者：
Compton, Carolyn C.;Hickerson, William;Press, William
通讯作者：
Press, William
DOI：
10.1001/jama.1989.03430150093032
发表时间：
1989-10
期刊：
JAMA
影响因子：
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作者：
J. Hansbrough;S. Boyce;M. Cooper;T. Foreman
通讯作者：
J. Hansbrough;S. Boyce;M. Cooper;T. Foreman