Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart Study.
Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart Study.
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DOI：
10.1136/heartjnl-2011-301080
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Vaccarino V
中科院分区：
文献类型：
--
作者：
Su S;Votaw J;Faber T;Khan D;Bremner JD;Goldberg J;Nichols K;Van Tosh A;Vaccarino V
To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). Cross-sectional twin study. General clinical research centre of a university hospital at Atlanta, USA. A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. All twins underwent imaging of MBF with PET 13NH3 at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.
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DOI：
10.1375/twin.5.5.476
发表时间：
2002-10-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Goldberg, J;Curran, B;Boyko, EJ
通讯作者：
Boyko, EJ
影响因子：
37.8
作者：
CZERNIN, J;MULLER, P;SCHELBERT, HR
通讯作者：
SCHELBERT, HR
影响因子：
14
作者：
Schindler, Thomas H.;Schelbert, Heinrich R.;Dilsizian, Vasken
通讯作者：
Dilsizian, Vasken
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
3.5
作者：
Broadbent, Helen M.;Peden, John F.;Watkins, Hugh
通讯作者：
Watkins, Hugh