CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence.
CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence.
复制标题
CD73/NT5E介导的AURKA泛素化通过调节肝星状细胞衰老来调节酒精性肝纤维化。
DOI:
10.7150/ijbs.80461
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发表时间:
2023
影响因子:
9.2
通讯作者:
Lv X
中科院分区:
文献类型:
--
作者:
Liu Z;Wu B;Liu X;Wu X;Du J;Xia G;Cai J;Zhu H;Sheng X;Zhang M;Xu J;Xu T;Lv X
Alcohol-related liver disease (ALD) is the most common chronic liver disease worldwide; however, no effective treatment to prevent the progression of alcohol-related liver fibrosis (ALF) is available. CD73/NT5E, a nucleotidase, controls cellular homeostasis by combining extracellular purinergic signaling with intracellular kinase activity and gene transcription and is associated with cell proliferation, differentiation, and death. In this study, we demonstrated that CD73/NT5E had a more significant regulatory effect on the activation, proliferation, and apoptosis of HSCs compared with that of CD39/ENTPD1. We examined the expression of CD73/NT5E in the normal and fibrotic human livers. The absence of CD73/NT5E was protective in mouse models of ALF. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that CD73/NT5E overexpression was related to the p53 signaling pathway, which regulates cell senescence. Proteins interacting with p53 were predicted using the STRING database. The overlap between proteomic analysis and STRING databases was for Aurora kinase A (AURKA), a cell cycle-regulated kinase. Coimmunoprecipitation (co-IP) assay and molecular docking confirmed that CD73/NT5E directly interacted with AURKA. We found that overexpression of CD73/NT5E inhibited AURKA ubiquitination, whereas p53 signaling was downregulated. Mechanistically, CD73/NT5E regulated ALF and the activation and senescence of stellate cells by binding to AURKA. These findings indicate that CD73/NT5E is a potential therapeutic target for ALF.
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影响因子:
12.4
作者:
Li X;Xu W;Kang W;Wong SH;Wang M;Zhou Y;Fang X;Zhang X;Yang H;Wong CH;To KF;Chan SL;Chan MTV;Sung JJY;Wu WKK;Yu J
通讯作者:
Yu J
影响因子:
64.8
作者:
通讯作者:
--
影响因子:
13.5
作者:
Kong, Xiaoni;Feng, Dechun;Wang, Hua;Hong, Feng;Bertola, Adeline;Wang, Fu-Sheng;Gao, Bin
通讯作者:
Gao, Bin
影响因子:
16.1
作者:
Higashi T;Friedman SL;Hoshida Y
通讯作者:
Hoshida Y
影响因子:
168.9
作者:
Bryazka, Dana;Reitsma, Marissa B.;Griswold, Max G.;Abate, Kalkidan Hassen;Abbafati, Cristiana;Kangevari, Mohsen Abbasi;Kangevari, Zeinab Abbasi;Abdoli, Amir;Abdollahi, Mohammad;Abdullah, Abu Yousuf Md;Abhilash, E. S.;Abu Gharbieh, Eman;Acuna, Juan Manuel;Addolorato, Giovanni;Adebayo, Oladimeji M.;Adekanmbi, Victor;Adhikari, Kishor;Adhikari, Sangeet;Adnani, Qorinah Estiningtyas Sakilah;Afzal, Saira;Agegnehu, Wubetu Yimam;Aggarwal, Manik;Ahinkorah, Bright Opoku;Ahmad, Araz Ramazan;Ahmad, Sajjad;Ahmad, Tauseef;Ahmadi, Ali;Ahmadi, Sepideh;Ahmed, Haroon;Rashid, Tarik Ahmed;Akunna, Chisom Joyqueenet;Al Hamad, Hanadi;Alam, Md Zakiul;Alem, Dejene Tsegaye;Alene, Kefyalew Addis;Alimohamadi, Yousef;Alizadeh, Atiyeh;Allel, Kasim;Alonso, Jordi;Alvand, Saba;Guzman, Nelson Alvis;Amare, Firehiwot;Ameyaw, Edward Kwabena;Amiri, Sohrab;Ancuceanu, Robert;Anderson, Jason A.;Andrei, Catalina Liliana;Andrei, Tudorel;Arabloo, Jalal;Arshad, Muhammad;Artamonov, Anton A.;Aryan, Zahra;Asaad, Malke;Asemahagn, Mulusew A.;Burt, Thomas Astell;Athari, Seyyed Shamsadin;Atnafu, Desta Debalkie;Atorkey, Prince;Atreya, Alok;Ausloos, Floriane;Ausloos, Marcel;Ayano, Getinet;Ayanore, Martin Amogre;Ayinde, Olatunde O.;Mateos, Jose L. Ayuso;Azadnajafabad, Sina;Azanaw, Melkalem Mamuye;Khyavy, Mohammadreza Azangou;Jafari, Amirhossein Azari;Azzam, Ahmed Y.;Badiye, Ashish D.;Bagheri, Nasser;Bagherieh, Sara;Bairwa, Mohan;Bakkannavar, Shankar M.;Bakshi, Ravleen Kaur;Balchut, Awraris Hailu;Null, Tilxrnighausen;Barra, Fabio;Barrow, Amadou;Baskaran, Pritish;Belo, Luis;Bennett, Derrick A.;Bensenor, Isabela M.;Bhagavathula, Akshaya Srikanth;Bhala, Neeraj;Bhalla, Ashish;Bhardwaj, Nikha;Bhardwaj, Pankaj;Bhaskar, Sonu;Bhattacharyya, Krittika;Bhojaraja, Vijayalakshmi S.;Bintoro, Bagas Suryo;Blokhina, Elena A. Elena;Bodicha, Belay Boda Abule;Boloor, Archith;Bosetti, Cristina;Braithwaite, Dejana;Brenner, Hermann;Briko, Nikolay Ivanovich;Brunoni, Andre R.;Butt, Zahid A.;Cao, Chao;Cao, Yin;Cardenas, Rosario;Carvalho, Andre F.;Carvalho, Marcia;Maia, Joao Mauricio Castaldelli;Castelpietra, Giulio;de Araujo, Luis F. S. Castro;Cattaruzza, Maria Sofia;Chakraborty, Promit Ananyo;Charan, Jaykaran;Chattu, Vijay Kumar;Chaurasia, Akhilanand;Cherbuin, Nicolas;Dinh Toi Chu;Chudal, Nandita;Chung, Sheng Chia;Churko, Chuchu;Ciobanu, Liliana G.;Cirillo, Massimo;Claro, Rafael M.;Costanzo, Simona;Cowden, Richard G.;Criqui, Michael H.;Martins, Natalia Cruz;Culbreth, Garland T.;Dachew, Berihun Assefa;Dadras, Omid;Dai, Xiaochen;Damiani, Giovanni;Dandona, Lalit;Dandona, Rakhi;Daniel, Beniam Darge;Danielewicz, Anna;Gela, Jiregna Darega;Davletov, Kairat;de Araujo, Jacyra Azevedo Paiva;de Sa Junior, Antonio Reis;Debela, Sisay Abebe;Dehghan, Azizallah;Demetriades, Andreas K.;Molla, Meseret Derbew;Desai, Rupak;Desta, Abebaw Alemayehu;da Silva, Diana Dias;Diaz, Daniel;Digesa, Lankamo Ena;Diress, Mengistie;Dodangeh, Milad;Dongarwar, Deepa;Dorostkar, Fariba;Dsouza, Haneil Larson;Duko, Bereket;Duncan, Bruce B.;Edvardsson, Kristina;Ekholuenetale, Michael;Elgar, Frank J.;Elhadi, Muhammed;Elmonem, Mohamed A.;Endries, Aman Yesuf;Eskandarieh, Sharareh;Etemadimanesh, Azin;Fagbamigbe, Adeniyi Francis;Fakhradiyev, Ildar Ravisovich;Farahmand, Fatemeh;Sa Farinha, Carla Sofia E.;Faro, Andre;Farzadfar, Farshad;Fatehizadeh, Ali;Fauk, Nelsensius Klau;Feigin, Valery L.;Feldman, Rachel;Feng, Xiaoqi;Fentaw, Zinabu;Ferrero, Simone;Desideri, Lorenzo Ferro;Filip, Irina;Fischer, Florian;Francis, Joel Msafiri;Franklin, Richard Charles;Gaal, Peter Andras;Gad, Mohamed M.;Gallus, Silvano;Galvano, Fabio;Ganesan, Balasankar;Garg, Tushar;Gebrehiwot, Mesfin Gebrehiwot Damtew;Gebremeskel, Teferi Gebru;Gebremichael, Mathewos Alemu;Gemechu, Tadele Regasa;Getacher, Lemma;Getachew, Motuma Erena;Obsa, Abera Getachew;Getie, Asmare;Ghaderi, Amir;Ghafourifard, Mansour;Ghajar, Alireza;Ghamari, Seyyed Hadi;Ghandour, Lilian A.;Nour, Mohammad Ghasemi;Ghashghaee, Ahmad;Ghozy, Sherief;Glozah, Franklin N.;Glushkova, Ekaterina Vladimirovna;Godos, Justyna;Goel, Amit;Goharinezhad, Salime;Golechha, Mahaveer;Goleij, Pouya;Golitaleb, Mohamad;Greaves, Felix;Grivna, Michal;Grosso, Giuseppe;Gudayu, Temesgen Worku;Gupta, Bhawna;Gupta, Rajeev;Gupta, Sapna;Gupta, Veer Bala;Gupta, Vivek Kumar;Nejad, Nima Hafezi;Mirzaian, Arvin Haj;Hall, Brian J.;Halwani, Rabih;Handiso, Tiilahun Beyene;Hankey, Graeme J.;Hariri, Sanam;Haro, Josep Maria;Hasaballah, Ahmed, I;Moghaddam, Hossein Hassanian;Hay, Simon, I;Hayat, Khezar;Heidari, Golnaz;Heidari, Mohammad;Hendrie, Delia;Herteliu, Claudiu;Heyi, Demisu Zenbaba;Hezam, Kamal;Hlongwa, Mbuzeleni Mbuzeleni;Holla, Ramesh;Hossain, Md Mahbub;Hossain, Sahadat;Hosseini, Seyed Kianoosh;Hosseinzadeh, Mehdi;Hostiuc, Mihaela;Hostiuc, Sorin;Hu, Guoqing;Huang, Junjie;Hussain, Salman;Ibitoye, Segun Emmanuel;Ilic, Irena M.;Ilic, Milena D.;Immurana, Mustapha;Irham, Lalu Muhammad;Islam, M. Mofizul;Islam, Rakibul M.;Islam, Sheikh Mohammed Shariful;Iso, Hiroyasu;Itumalla, Ramaiah;Iwagami, Masao;Jabbarinejad, Roxana;Jacob, Louis;Jakovljevic, Mihajlo;Jamalpoor, Zahra;Jamshidi, Elham;Jayapal, Sathish Kumar;Jayarajah, Umesh Umesh;Jayawardena, Ranil;Jebai, Rime;Jeddi, Seyed Ali;Jema, Alelign Tasew;Jha, Ravi Prakash;Jindal, Har Ashish;Jonas, Jost B.;Joo, Tamas;Joseph, Nitin;Joukar, Farahnaz;Jozwiak, Jacek Jerzy;Jurisson, Mikk;Kabir, Ali;Kabthymer, Robel Hussen;Kamble, Bhushan Dattatray;Kandel, Himal;Kanno, Girum Gebremeskel;Kapoor, Neeti;Karaye, Ibraheem M.;Karimi, Salah Eddin;Kassa, Bekalu Getnet;Kaur, Rimple Jeet;Kayode, Gbenga A.;Keykhaei, Mohammad;Khajuria, Himanshu;Khalilov, Rovshan;Khan, Imteyaz A.;Ab Khan, Moien;Kim, Hanna;Kim, Jihee;Kim, Min Seo;Kimokoti, Ruth W.;Kivimaki, Mika;Klymchuk, Vitalii;Knudsen, Ann Kristin Skrindo;Kolahi, Ali Asghar;Korshunov, Vladimir Andreevich;Koyanagi, Ai;Krishan, Kewal;Krishnamoorthy, Yuvaraj;Kumar, G. Anil;Kumar, Nithin;Ben Lacey;Lallukka, Tea;Lasrado, Savita;Lau, Jerrald;Lee, Sang Woong;Lee, Wei Chen;Lee, Yo Han;Lim, Lee Ling;Lim, Stephen S.;Lobo, Stany W.;Lopukhov, Platon D.;Lorkowski, Stefan;Lozano, Rafael;Lucchetti, Giancarlo;Madadizadeh, Farzan;Mahjoub, Soleiman;Mahmoodpoor, Ata;Mahumud, Rashidul Alam;Makki, Alaa;Malekpour, Mohammad Reza;Manjunatha, Narayana;Mansouri, Borhan;Mansournia, Mohammad Ali;Raga, Jose Martinez;Villa, Francisco A. Martinez;Matzopoulos, Richard;Maulik, Pallab K.;Mayeli, Mahsa;McGrath, John J.;Meena, Jitendra Kumar;Nasab, Entezar Mehrabi;Menezes, Ritesh G.;Mensink, Gert B. M.;Mentis, Alexios Fotios A.;Meretoja, Atte;Merga, Bedasa Taye;Mestrovic, Tomislav;Jonasson, Junmei Miao;Miazgowski, Bartosz;de Sa, Ana Carolina Micheletti Gomide Nogueira;Miller, Ted R.;Mini, Gk;Mirica, Andreea;Mirijello, Antonio;Mirmoeeni, Seyyedmohammadsadeq;Mirrakhimov, Erkin M.;Misra, Sanjeev;Moazen, Babak;Mobarakabadi, Maryam;Moccia, Marcello;Mohammad, Yousef;Mohammadi, Esmaeil;Hafshejani, Abdollah Mohammadian;Mohammed, Teroj Abdulrahman;Moka, Nagabhishek;Mokdad, Ali H.;Momtazmanesh, Sara;Moradi, Yousef;Mostafavi, Ebrahim;Mubarik, Sumaira;Mullany, Erin C.;Mulugeta, Beemnet Tekabe;Zamora, Efren Murillo;Murray, Christopher J. L.;Mwita, Julius C.;Naghavi, Mohsen;Naimzada, Mukhammad David;Nangia, Vinay;Nayak, Biswa Prakash;Negoi, Ionut;Negoi, Ruxandra Irina;Nejadghaderi, Seyed Aria;Nepal, Samata;Neupane, Sudan Prasad Prasad;Kandel, Sandhya Neupane;Nigatu, Yeshambel T.;Nowroozi, Ali;Nuruzzaman, Khan M.;Nzoputam, Chimezie Igwegbe;Obamiro, Kehinde O.;Ogbo, Felix Akpojene;Oguntade, Ayodipupo Sikiru;Aliabad, Hassan Okati;Olakunde, Babayemi Oluwaseun;Oliveira, Glaucia Maria Moraes;Bali, Ahmed Omar;Omer, Emad;Altamirano, Doris V. Ortega;Otoiu, Adrian;Otstavnov, Stanislav S.;Oumer, Bilcha;Mahesh, P. A.;Monedero, Alicia Padron;Palladino, Raffaele;Pana, Adrian;Jonas, Songhomitra Panda;Pandey, Ashok;Pardhan, Shahina;Parekh, Tarang;Park, Eun Kee;Parry, Charles D. H.;Kan, Fatemeh Pashazadeh;Patel, Jay;Pati, Siddhartha;Patton, George C.;Paudel, Uttam;Pawar, Shrikant;Peden, Amy E.;Petcu, Ionela Roxana;Phillips, Michael R.;Pinheiro, Marina;Plotnikov, Evgenii;Pradhan, Pranil Man Singh;Prashant, Akila;Quan, Jianchao;Radfar, Amir;Rafiei, Alireza;Raghav, Pankaja Raghav;Movaghar, Vafa Rahimi;Rahman, Azizur;Rahman, Md Mosfequr;Rahman, Mosiur;Rahmani, Amir Masoud;Rahmani, Shayan;Ranabhat, Chhabi Lal;Ranasinghe, Priyanga;Rao, Chythra R.;Rasali, Drona Prakash;Rashidi, Mohammad Mahdi;Ratan, Zubair Ahmed;Rawaf, David Laith;Rawaf, Salman;Rawal, Lal;Renzaho, Andre M. N.;Rezaei, Negar;Rezaei, Saeid;Rezaeian, Mohsen;Riahi, Seyed Mohammad;Rodriguez, Esperanza Romero;Roth, Gregory A.;Rwegerera, Godfrey M.;Saddik, Basema;Sadeghi, Erfan;Sadeghian, Reihaneh;Saeed, Umar;Saeedi, Farhad;Sagar, Rajesh;Sahebkar, Amirhossein;Sahoo, Harihar;Sahraian, Mohammad Ali;Rahman, Km Saif Ur;Salahi, Sarvenaz;Salimzadeh, Hamideh;Samy, Abdallah M.;Sanmarchi, Francesco;Milicevic, Milena M. Santric;Sarikhani, Yaser;Sathian, Brijesh;Saya, Ganesh Kumar;Sayyah, Mehdi;Schmidt, Maria Ines;Schutte, Aletta Elisabeth;Schwarzinger, Michael;Schwebel, David C.;Seidu, Abdul Aziz;Kumar, Nachimuthu Senthil;SeyedAlinaghi, SeyedAhmad;Seylani, Allen;Sha, Feng;Shahin, Sarvenaz;Sanavi, Fariba Shahraki;Shahrokhi, Shayan;Shaikh, Masood Ali;Shaker, Elaheh;Shakhmardanov, Murad Ziyaudinovich;Beyranvand, Mehran Shams;Sheikhbahaei, Sara;Sheikhi, Rahim Ali;Shetty, Adithi;Shetty, Jeevan K.;Shiferaw, Damtew Solomon;Shigematsu, Mika;Shiri, Rahman;Shirkoohi, Reza;Shivakumar, K. M.;Shivarov, Velizar;Shobeiri, Parnian;Shrestha, Roman;Sidemo, Negussie Boti;Sigfusdottir, Inga Dora;Silva, Diego Augusto Santos;da Silva, Natacha Torres;Singh, Jasvinder A.;Singh, Surjit;Skryabin, Valentin Yurievich;Skryabina, Anna Aleksandrovna;Sleet, David A.;Solmi, Marco;Solomon, Yonatan;Song, Suhang;Song, Yimeng;Sorensen, Reed J. D.;Soshnikov, Sergey;Soyiri, Ireneous N.;Stein, Dan J.;Subba, Sonu Hangma;Szocska, Miklos;Seisdedos, Rafael Tabares;Tabuchi, Takahiro;Taheri, Majid;Tan, Ker Kan;Tareke, Minale;Tarkang, Elvis Enowbeyang;Temesgen, Gebremaryam;Temesgen, Worku Animaw;Temsah, Mohamad Hani;Thankappan, Kavumpurathu Raman;Thapar, Rekha;Thomas, Nikhil Kenny;Tiruneh, Chalachew;Todorovic, Jovana;Torrado, Marco;Touvier, Mathilde;Palone, Marcos Roberto Tovani;Mai Thi Ngoc Tran;Llimos, Sergi Trias;Tripathy, Jaya Prasad;Vakilian, Alireza;Valizadeh, Rohollah;Varmaghani, Mehdi;Varthya, Shoban Babu;Vasankari, Tommi Juhani;Vos, Theo;Wagaye, Birhanu;Waheed, Yasir;Walde, Mandaras Tariku;Wang, Cong;Wang, Yanzhong;Wang, Yuan Pang;Westerman, Ronny;Wickramasinghe, Nuwan Darshana;Wubetu, Abate Dargie;Xu, Suowen;Yamagishi, Kazumasa;Yang, Lin;Yesera, Gesila Endashaw E.;Yigit, Arzu;Yigit, Vahit;Yimaw, Ayenew Engida;Yon, Dong Keon;Yonemoto, Naohiro;Yu, Chuanhua;Zadey, Siddhesh;Zahir, Mazyar;Zare, Iman;Zastrozhin, Mikhail Sergeevich;Zastrozhina, Anasthasia;Zhang, Zhi Jiang;Zhong, Chenwen;Zmaili, Mohammad;Zuniga, Yves Miel H.;Gakidou, Emmanuela;Madureira-Carvalho, Aurea M.
通讯作者:
Madureira-Carvalho, Aurea M.