Connexins, pannexins, innexins: novel roles of "hemi-channels".
Connexins, pannexins, innexins: novel roles of "hemi-channels".
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DOI:
10.1007/s00424-008-0591-5
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发表时间:
2009-04
影响因子:
4.5
通讯作者:
Meda, Paolo
中科院分区:
文献类型:
--
作者:
Scemes, Eliana;Spray, David C.;Meda, Paolo
The advent of multicellular organisms, some 800 million years ago, necessitated the development of mechanisms for cell-to-cell synchronization and for the spread of signals across increasingly large cell populations. Many structures and mechanisms have evolved to achieve such functions. Among these mechanisms, one which is prominent in both the invertebrate and the vertebrate world, across the entire phylogenetic scale, involves the transmembrane flux of large cytosolic and extracellular molecules. These fluxes, in turn, are dependent on the formation of specific channels that in all animal classes are made by tetra-span integral membrane proteins (Fig. 1).
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