Connexins, pannexins, innexins: novel roles of "hemi-channels".

Connexins, pannexins, innexins: novel roles of "hemi-channels".
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DOI:
10.1007/s00424-008-0591-5
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发表时间:
2009-04
影响因子:
4.5
通讯作者:
Meda, Paolo
Meda, Paolo
中科院分区:
医学3区
文献类型:
--
作者:
Scemes, Eliana;Spray, David C.;Meda, Paolo

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大约8亿年前,多细胞生物的出现使得细胞间同步化机制的发展和信号在越来越大的细胞群中传播成为必要。许多结构和机制已经演变为实现这些职能。在这些机制中,在无脊椎动物和脊椎动物世界中,在整个系统发育尺度上都很突出的一个机制涉及大的细胞溶质和细胞外分子的跨膜通量。反过来,这些通量依赖于特定通道的形成,在所有动物类别中,这些通道都是由四跨度整合膜蛋白制成的(图1)。
The advent of multicellular organisms, some 800 million years ago, necessitated the development of mechanisms for cell-to-cell synchronization and for the spread of signals across increasingly large cell populations. Many structures and mechanisms have evolved to achieve such functions. Among these mechanisms, one which is prominent in both the invertebrate and the vertebrate world, across the entire phylogenetic scale, involves the transmembrane flux of large cytosolic and extracellular molecules. These fluxes, in turn, are dependent on the formation of specific channels that in all animal classes are made by tetra-span integral membrane proteins (Fig. 1).
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