Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease.
Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2014.09.011
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发表时间：
2015-02
影响因子：
4.2
通讯作者：
Frisoni GB
中科院分区：
文献类型：
--
作者：
Babiloni C;Del Percio C;Boccardi M;Lizio R;Lopez S;Carducci F;Marzano N;Soricelli A;Ferri R;Triggiani AI;Prestia A;Salinari S;Rasser PE;Basar E;Famà F;Nobili F;Yener G;Emek-Savaş DD;Gesualdo L;Mundi C;Thompson PM;Rossini PM;Frisoni GB
在遗忘性轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 患者中，在群体水平上，枕叶静息态脑电图 (EEG) α 节律源异常。在这里，我们评估了以下假设：这些枕叶源的振幅与磁共振成像 (MRI) 测量的枕叶神经变性有关。记录了 45 名健康老年人 (Nold)、100 名 MCI 和 90 名 AD 受试者的静息状态闭眼脑电图节律。枕叶神经退行性病变以灰质密度 (GMD) 的加权平均值为索引，由结构 MRI 估计。感兴趣的 EEG 节律为 α 1 (8–10.5 Hz) 和 α 2 (10.5–13 Hz)。通过低分辨率脑电磁断层扫描（LORETA）估计脑电图皮质源。结果显示，Nold、MCI 和 AD 受试者作为一个整体，枕骨 GMD 与枕骨 α 1 源振幅呈正相关（r=0.3，p=0.000004，N=235）。此外，所有受试者的简易精神状态评估 (MMSE) 评分显示，枕骨 α 1 源的振幅与认知状态之间存在正相关性 (r=0.38，p=0.000001，N=235)。最后，枕叶 α 1 源的幅度允许对个体 Nold 和 AD 受试者进行适度分类（敏感性：87.8%；特异性：66.7%；接受者操作特征 (ROC) 曲线下面积：0.81）。这些结果表明，静息状态α节律的枕叶源的振幅与病理性衰老过程中枕叶的AD神经变性有关。
Occipital sources of resting state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Here we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging (MRI). Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density (GMD), estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8–10.5 Hz) and alpha 2 (10.5–13 Hz). EEG cortical sources were estimated by low resolution brain electromagnetic tomography (LORETA). Results showed a positive correlation between occipital GMD and amplitude of occipital alpha 1 sources in Nold, MCI and AD subjects as a whole group (r=0.3, p=0.000004, N=235). Furthermore, there was a positive correlation between amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Evaluation (MMSE) score across all subjects (r=0.38, p=0.000001, N=235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the Receiver Operating Characteristic (ROC) curve: 0.81). These results suggest that the amplitude of occipital sources of resting state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathological aging.
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DOI：
10.1080/13803390490515540
发表时间：
2004-11-01
影响因子：
2.2
作者：
Chandler, MJ;Lacritz, LH;Cullum, CM
通讯作者：
Cullum, CM
影响因子：
5.7
作者：
Baron, JC;Chételat, G;Eustache, F
通讯作者：
Eustache, F
影响因子：
7.5
作者：
Buscema, Massimo;Rossini, Paolo;Grossi, Enzo
通讯作者：
Grossi, Enzo
影响因子：
14.5
作者：
DERENZI, E;VIGNOLO, LA
通讯作者：
VIGNOLO, LA
影响因子：
4.7
作者：
Dierks, T;Jelic, V;Nordberg, A
通讯作者：
Nordberg, A