Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression.
Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression.
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DOI：
10.1016/j.bbih.2021.100320
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Bollinger JL
中科院分区：
文献类型：
--
作者：
Bollinger JL
女性比男性更容易患重度抑郁症 (MDD)，并且 MDD 症状更严重。越来越多的证据表明，重度抑郁症的性别差异可能部分是由性别特异性神经生物学机制驱动的。慢性压力是 MDD 的一个重要危险因素，临床前啮齿动物模型显示出男性和女性压力诱导的神经重塑和认知行为功能障碍的不同模式。例如，慢性压力会导致雄性啮齿动物内侧前额叶皮质的突触丢失，但对雌性啮齿动物的突触数量没有影响或增加。最近的报告表明，小胶质细胞（大脑的免疫细胞）与 MDD 有关，研究结果表明，临床前应激模型和 MDD 患者中都存在性别特异性的小胶质细胞特征。鉴于小胶质细胞可以重塑神经结构、调节突触传递并影响随后的行为变化，因此小胶质细胞通路可能有助于对男性和女性的神经可塑性和功能产生不同的应激影响。因此，本综述研究了临床前应激模型和 MDD 患者中性别特异性小胶质细胞-神经元相互作用的证据。本文强调的发现表明，男性和女性的小胶质细胞贡献不同，并表明未来调查压力相关疾病的研究应以性别依赖性神经生物学和行为发现为指导。检查这些途径为更丰富地理解大脑、行为和免疫以及基于心理神经免疫学的个性化医疗创新应用提供了一条明确的途径。
Women suffer from major depressive disorder (MDD) more often than men and report greater MDD symptom severity. Mounting evidence suggests that sex differences in MDD may be driven, in part, by sex-specific neurobiological mechanisms. Chronic stress is a significant risk factor in MDD, and preclinical rodent models show differential patterns of stress-induced neural remodeling and cognitive-behavioral dysfunction in males and females. For instance, chronic stress leads to synapse loss in the medial prefrontal cortex in male rodents yet has either no effect on- or increases-synapse number in females. Recent reports have implicated microglia, the immune cells of the brain, in MDD, and findings demonstrate sex-specific microglial signatures in both preclinical stress models and MDD patients. Given that microglia can remodel neural architecture, modulate synaptic transmission, and affect subsequent changes in behavior, it is plausible that microglial pathways contribute to differential stress effects on neuroplasticity and function in males and females. As such, this review examines the evidence for sex-specific microglia-neuron interactions in preclinical stress models and in patients with MDD. Discoveries highlighted herein demonstrate divergent microglial contributions in males and females and suggest that future studies investigating stress-linked disorders should be guided by sex-dependent neurobiological and behavioral findings. Examining these pathways represents a clear avenue toward both a richer understanding of brain, behavior, and immunity, and innovative psychoneuroimmunology-based applications in personalized medicine.
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DOI：
10.1016/j.bbi.2015.10.003
发表时间：
2016-02
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Bollinger JL;Bergeon Burns CM;Wellman CL
通讯作者：
Wellman CL
影响因子：
8.8
作者：
Eyo UB;Mo M;Yi MH;Murugan M;Liu J;Yarlagadda R;Margolis DJ;Xu P;Wu LJ
通讯作者：
Wu LJ
影响因子：
2.7
作者：
Conrad, CD;Grote, KA;Ferayorni, A
通讯作者：
Ferayorni, A
影响因子：
5
作者：
Gaspar R;Soares-Cunha C;Domingues AV;Coimbra B;Baptista FI;Pinto L;Ambrósio AF;Rodrigues AJ;Gomes CA
通讯作者：
Gomes CA
影响因子：
3.3
作者：
Garrett, J. E.;Wellman, C. L.
通讯作者：
Wellman, C. L.