Carbohydrate metabolism during vertebrate appendage regeneration: what is its role? How is it regulated?: A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis.
Carbohydrate metabolism during vertebrate appendage regeneration: what is its role? How is it regulated?: A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis.
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DOI：
10.1002/bies.201300110
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发表时间：
2014-01
期刊：
影响因子：
4
通讯作者：
Amaya, Enrique
中科院分区：
文献类型：
--
作者：
Love, Nick R.;Ziegler, Mathias;Chen, Yaoyao;Amaya, Enrique
关键词：
我们最近研究了爪蟾蝌蚪尾附肢再生过程中的基因表达，发现碳水化合物调控基因在再生过程中发生了显着改变。在这篇文章中，我们推测，这些基因表达的变化在再生过程中发挥重要作用，刺激合成代谢途径所需的重建一个新的附件。我们假设在再生过程中，细胞利用瘦素、slc2a3、胰岛素原、g6pd、hif1α表达、受体酪氨酸激酶（RTK）信号传导和活性氧（ROS）的产生来促进葡萄糖进入糖酵解和磷酸戊糖途径（PPP），从而刺激大分子生物合成。我们认为，这种代谢的转变是不可或缺的附件再生程序，非洲爪蟾模型是一个强大的实验系统，以进一步探讨这一现象。
We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to promote glucose entry into glycolysis and the pentose phosphate pathway (PPP), thus stimulating macromolecular biosynthesis. We suggest that this metabolic shift is integral to the appendage regeneration program and that the Xenopus model is a powerful experimental system to further explore this phenomenon.
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DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.6
作者：
Gargioli, C;Slack, JMW
通讯作者：
Slack, JMW
影响因子：
11.8
作者：
Beck, CW;Christen, B;Slack, JMW
通讯作者：
Slack, JMW
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
64.8
作者：
KINTNER, CR;BROCKES, JP
通讯作者：
BROCKES, JP