Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies.
Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies.
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DOI：
10.3390/jcm11154457
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发表时间：
2022-07-30
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
铁是真菌病原体繁殖和生存所必需的必需微量金属。后者已经发展出各种机制从哺乳动物宿主那里获取铁，并与哺乳动物宿主一起参与对铁的统治地位的持续斗争。侵袭性真菌感染是血液恶性肿瘤患者治疗中的一个重要问题，与显着的发病率和死亡率相关。这些患者的侵袭性临床感染的诊断很复杂，而且必须尽早进行治疗也很困难。有几项研究表明铁过载与感染易感性增加之间可能存在联系。这种联系也与血液恶性肿瘤患者和接受同种异体造血干细胞移植治疗的患者相关。铁及其代谢在各种侵袭性真菌感染的毒力和发病机制中的作用很有趣，到目前为止，有一些证据将侵袭性真菌感染与铁或铁超载联系起来。阐明铁和铁超负荷与侵袭性真菌感染易感性之间的可能关联，对于更好地预防和治疗血液恶性肿瘤患者的这些感染可能很重要。
Iron is an essential trace metal necessary for the reproduction and survival of fungal pathogens. The latter have developed various mechanisms to acquire iron from their mammalian hosts, with whom they participate in a continuous struggle for dominance over iron. Invasive fungal infections are an important problem in the treatment of patients with hematological malignancies, and they are associated with significant morbidity and mortality. The diagnosis of invasive clinical infections in these patients is complex, and the treatment, which must occur as early as possible, is difficult. There are several studies that have shown a possible link between iron overload and an increased susceptibility to infections. This link is also relevant for patients with hematological malignancies and for those treated with allogeneic hematopoietic stem cell transplantation. The role of iron and its metabolism in the virulence and pathogenesis of various invasive fungal infections is intriguing, and so far, there is some evidence linking invasive fungal infections to iron or iron overload. Clarifying the possible association of iron and iron overload with susceptibility to invasive fungal infections could be important for a better prevention and treatment of these infections in patients with hematological malignancies.
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