A New Glioblastoma Targeting Therapy Concept by Using Square Shaped Janus Drug Carrier Assisted with 3D Printed External Magnetic Wearables
A New Glioblastoma Targeting Therapy Concept by Using Square Shaped Janus Drug Carrier Assisted with 3D Printed External Magnetic Wearables
复制标题
使用方形 Janus 药物载体辅助 3D 打印外部磁性可穿戴设备的胶质母细胞瘤靶向治疗新概念
DOI：
10.1002/ppsc.201800384
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发表时间：
2018-12
影响因子：
2.7
通讯作者：
Xiaolei Wang
中科院分区：
文献类型：
--
作者：
Chaochao Wei;Yu Liu;Xue Tian;Ruolei Li;Wanqing Tong;Shuhua Wang;Hongbo Xin;Hu Ping;Xiaolei Wang
目前，恶性胶质瘤的临床治疗仍不尽如人意。血脑屏障的存在阻碍了大多数化学和生物药物到达脑组织。本研究合成了一种具有高红外响应性、大载药量和可靠磁靶向能力的方形Janus载药系统。结合外部3D打印的磁性可穿戴设备，该运载系统在体外和体内测试中都能有效穿透血脑屏障，因此应用于两种不同的靶向肿瘤治疗（包括胶质瘤）。动物实验证明了所提出的系统的多种治疗效果。后续研究表明，所得载体对动物脏器无明显毒性作用。与经典的生物化学靶向方法不同，这项研究独特地将多孔Janus纳米载体与外部可穿戴磁性导向装置（物理靶向）结合起来，这是一种有前途的靶向治疗概念，具有令人印象深刻的灵活性和可靠性。
At present, the clinical treatment of malignant glioma is still unsatisfactory. The existence of the blood–brain barrier hinders most chemical and biological drugs to reach the brain tissue. In this study, a square‐shaped Janus drug carrying system, which incorporated with high infrared responsiveness, large drug loading capacity, and reliable magnetic targeting capabilities is synthesized. Combined with an external 3D printed magnetic wearable equipment, this carrying system can effectively penetrate the blood–brain barrier in both in vitro and in vivo tests, it is thus applied to two different targeting tumor therapies (including glioma). Animal experiments demonstrate the multiple therapeutic effects of the proposed system. The subsequent studies imply that the obtained carrier has no obvious toxic effects on the organs of animals. Different from the classical biochemical targeting method, this study uniquely combines the porous Janus nanocarrier with an external wearable magnetic guidance device (physical targeting), which is a promising target therapeutic concept with impressive flexibility and reliability.
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