Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis.
Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0041941
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Dimitrakoff JD
中科院分区：
文献类型：
--
作者：
Cohen JM;Fagin AP;Hariton E;Niska JR;Pierce MW;Kuriyama A;Whelan JS;Jackson JL;Dimitrakoff JD
慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）已被治疗与几种不同的干预措施，有限的成功。本荟萃分析旨在使用美国国立卫生研究院-慢性前列腺炎症状指数（NIH-CPSI）审查所有报告CP/CPPS治疗干预的试验。我们检索了Medline、PubMed、科克伦疼痛、姑息和支持治疗试验、科克伦对照试验登记、CINAHL、ClinicalTrials.gov和NIDDK网站，检索时间为1947年至2011年12月31日，无语言或研究类型限制。纳入了所有持续至少6周的CP/CPPS RCT，每组至少10名参与者，并使用NIH-CPSI评分（CP/CPPS的标准）作为结局指标。每项研究的数据由两名独立的审查员提取。Gillbraith和I-squared图用于异质性检验，Eggers和Peters方法用于发表偏倚。使用成分方法评估质量，并使用元回归分析异质性的来源。美帕曲星、经皮胫神经刺激（PTNS）和由多沙唑嗪+布洛芬+硫代秋水仙碱苷（DIT）组成的三联疗法导致NIH-CPSI总分在临床和统计学上显著降低。相同的药物和有氧运动导致临床和统计学显著的NIH-CPSI疼痛领域评分降低。针刺、DIT和PTNS在NIH-CPSI排尿领域产生统计学和临床显著性降低。所有结局均发现统计学显著的安慰剂效应，时间分析显示所有治疗的疗效均随时间推移而增加。α-受体阻滞剂、抗生素和两者的组合未能显示统计学或临床显著的NIH-CPSI降低。该荟萃分析的结果反映了我们目前无法有效管理CP/CPPS。临床医生和研究人员必须考虑随着时间的推移安慰剂效应和治疗效果，并创造性地设计研究，以便我们能够更全面地阐明CP/CPPS的病因和治疗干预的作用。
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has been treated with several different interventions with limited success. This meta-analysis aims to review all trials reporting on therapeutic intervention for CP/CPPS using the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI). We searched Medline, PubMed, the Cochrane Pain, Palliative & Supportive Care Trials, the Cochrane Register of Controlled Trials, CINAHL, ClinicalTrials.gov, and the NIDDK website between 1947 and December 31, 2011 without language or study type restrictions. All RCTs for CP/CPPS lasting at least 6 weeks, with a minimum of 10 participants per arm, and using the NIH-CPSI score, the criterion standard for CP/CPPS, as an outcome measure were included. Data was extracted from each study by two independent reviewers. Gillbraith and I-squared plots were used for heterogeneity testing and Eggers and Peters methods for publication bias. Quality was assessed using a component approach and meta-regression was used to analyze sources of heterogeneity. Mepartricin, percutaneous tibial nerve stimulation (PTNS), and triple therapy comprised of doxazosin + ibuprofen + thiocolchicoside (DIT) resulted in clinically and statistically significant reduction in NIH-CPSI total score. The same agents and aerobic exercise resulted in clinically and statistically significant NIH-CPSI pain domain score reduction. Acupuncture, DIT, and PTNS were found to produce statistically and clinically significant reductions in the NIH-CPSI voiding domain. A statistically significant placebo effect was found for all outcomes and time analysis showed that efficacy of all treatments increased over time. Alpha-blockers, antibiotics, and combinations of the two failed to show statistically or clinically significant NIH-CPSI reductions. Results from this meta-analysis reflect our current inability to effectively manage CP/CPPS. Clinicians and researchers must consider placebo effect and treatment efficacy over time and design studies creatively so we can more fully elucidate the etiology and role of therapeutic intervention in CP/CPPS.
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影响因子：
2.1
作者：
Mehik, A;Alas, P;Helström, PJ
通讯作者：
Helström, PJ
影响因子：
2.1
作者：
Lee, Shaun Wen Huey;Liong, Men Long;Krieger, John N.
通讯作者：
Krieger, John N.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
1.6
作者：
Kabay, Sahin;Kabay, Sibel Canbaz;Ozden, Hilmi
通讯作者：
Ozden, Hilmi
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG