Interdependence of bronchial circulation and clearance of 99mTc-DTPA from the airway surface.
Interdependence of bronchial circulation and clearance of 99mTc-DTPA from the airway surface.
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支气管循环和 99mTc-DTPA 从气道表面清除的相互依赖性。
DOI：
10.1152/jappl.2001.90.4.1275
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Foster,WM
中科院分区：
文献类型：
--
作者：
Wagner,EM;Foster,WM
通身性脉管系统在多大程度上参与了传导气道中可溶颗粒的摄取尚未得到广泛的研究。在麻醉、通气的绵羊中，将6-10 μl锝-99m标记的二乙烯三胺五乙酸（99mTc-DTPA）通过微喷雾喷嘴注入第四代气道。插管支气管动脉灌注在对照流量（0.6 ml·min−1·kg−1）、高流量（1.8 ml·min−1·kg−1）和无流量（停止注射泵）之间变化。使用伽马相机成像监测放射性示踪剂的气道潴留，并采集静脉血。在对照灌注时，示踪剂在沉积部位30 min的保留率平均为20±6% （n= 7）。无流量时，保留率显著提高至32±8% （P= 0.03）。在另一组（n= 5）中，对照组保留率为13±4%，高流量导致示踪剂增加（25±4%；P= 0.04）。通过估算循环血容量来计算示踪剂的最大血吸收量，在控制流期间平均为总活度的16%。只有在高流量条件下，血液中的99mtc - dtpa降低（10%；P= 0.04）。大部分示踪剂通过显像显示纤毛粘液清除。在无流状态下，这一组分显著降低。结果表明，气道灌注减少和增加都限制了可溶示踪剂应用于传导气道的去除。
The extent to which the systemic vasculature is involved in soluble-particle uptake in the conducting airways has not been studied extensively. In anesthetized, ventilated sheep, 6–10 μl of technetium-99m-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) was delivered through a microspray nozzle to a fourth-generation airway. Perfusion of the cannulated bronchial artery was varied between control flow (0.6 ml · min−1· kg−1), high flow (1.8 ml · min−1· kg−1) or no flow (the infusion pump was stopped). Airway retention of the radioactive tracer was monitored using gamma camera imaging, and venous blood was sampled. During control perfusion, tracer retention at the site of deposition at 30 min averaged 20 ± 6% (n= 7). With no flow, retention was significantly elevated to 32 ± 8% (P= 0.03). In another group of sheep (n= 5) with a control retention of 13 ± 4%, high flow resulted in an increase in tracer (25 ± 4%;P= 0.04). Maximum blood uptake of tracer was calculated by estimating circulating blood volume and averaged 16% of total activity during control flow. Only during high-flow conditions was99mTc-DTPA in the blood decreased (10%;P= 0.04). Most of the tracer was cleared by mucociliary clearance as visualized by imaging. This component was substantially decreased during no flow. The results demonstrate that both decreased and increased airway perfusion limit removal of soluble tracer applied to the conducting airways.
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气道血流对肺部颗粒清除的重要性。
DOI：
10.1152/jappl.1996.81.5.1878
发表时间：
1996
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Wagner,EM;Foster,WM
通讯作者：
Foster,WM
麻醉绵羊支气管动脉闭塞后全身血流至肺部。
影响因子：
3.3
作者：
E. Baile;D. Minshall;P. Harrison;P. Dodek;P. Paré
通讯作者：
P. Paré
影响因子：
1.3
作者：
Justus F. Mueller;S. Schermer
通讯作者：
Justus F. Mueller;S. Schermer
乙酰甲胆碱引起的气道收缩的支气管循环逆转。
影响因子：
3.3
作者：
E. Wagner;W. Mitzner
通讯作者：
W. Mitzner
绵羊气管血流量和 99mTc-DTPA 的管腔清除率。
影响因子：
3.3
作者：
Z. Hanafi;D. Corfield;S. Webber;J. Widdicombe
通讯作者：
J. Widdicombe