CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens.
CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens.
复制标题
DOI：
10.1093/nar/gkn673
复制
发表时间：
2009-01
影响因子：
14.9
通讯作者：
Vasconcelos AT
中科院分区：
文献类型：
--
作者：
Almeida LG;Sakabe NJ;deOliveira AR;Silva MC;Mundstein AS;Cohen T;Chen YT;Chua R;Gurung S;Gnjatic S;Jungbluth AA;Caballero OL;Bairoch A;Kiesler E;White SL;Simpson AJ;Old LJ;Camargo AA;Vasconcelos AT
免疫反应的效力仍需得到有效利用以对抗人类癌症。然而，在黑色素瘤和其他肿瘤中发现T细胞靶点提高了癌症疫苗可用于诱导针对癌症的具有治疗效果的免疫反应的可能性。这些靶点，即癌 - 睾丸（CT）抗原，是在正常生殖组织以及不同组织学类型的肿瘤中优先表达的免疫原性蛋白质。针对CT抗原的治疗性癌症疫苗目前正处于后期临床试验阶段，以测试它们在手术切除原发肿瘤后是否能够延缓或预防肺癌和黑色素瘤的复发。CT抗原构成一个庞大但定义不明确的蛋白质家族，其表达具有显著的局限性。目前，关于这些蛋白质有大量信息，但数据分散在文献和多个生物信息数据库中。这里介绍的数据库，CT数据库（http://www.cta.lncc.br），整合了这些知识，以便于挖掘现有的大量数据，以及识别被声称是CT抗原但不具有其特征性受限表达模式的蛋白质。CT数据库不仅仅是一个CT抗原数据的存储库，因为所有可用信息都经过仔细整理和注释，大多数数据是专门针对CT抗原进行处理并本地存储的。从已知CT抗原的汇编开始，CT数据库提供基本信息，包括基因名称和别名、RefSeq登录号、基因组位置、已知的剪接变体、基因重复以及其他家族成员。从通过几种不同技术获得的公开数据中整理了正常和肿瘤组织中mRNA水平的基因表达情况。还提供了与癌症患者的mRNA和蛋白质表达以及抗原特异性免疫反应相关的人工整理数据，以及相关CT抗原文章的PubMed链接。
The potency of the immune response has still to be harnessed effectively to combat human cancers. However, the discovery of T-cell targets in melanomas and other tumors has raised the possibility that cancer vaccines can be used to induce a therapeutically effective immune response against cancer. The targets, cancer-testis (CT) antigens, are immunogenic proteins preferentially expressed in normal gametogenic tissues and different histological types of tumors. Therapeutic cancer vaccines directed against CT antigens are currently in late-stage clinical trials testing whether they can delay or prevent recurrence of lung cancer and melanoma following surgical removal of primary tumors. CT antigens constitute a large, but ill-defined, family of proteins that exhibit a remarkably restricted expression. Currently, there is a considerable amount of information about these proteins, but the data are scattered through the literature and in several bioinformatic databases. The database presented here, CTdatabase (http://www.cta.lncc.br), unifies this knowledge to facilitate both the mining of the existing deluge of data, and the identification of proteins alleged to be CT antigens, but that do not have their characteristic restricted expression pattern. CTdatabase is more than a repository of CT antigen data, since all the available information was carefully curated and annotated with most data being specifically processed for CT antigens and stored locally. Starting from a compilation of known CT antigens, CTdatabase provides basic information including gene names and aliases, RefSeq accession numbers, genomic location, known splicing variants, gene duplications and additional family members. Gene expression at the mRNA level in normal and tumor tissues has been collated from publicly available data obtained by several different technologies. Manually curated data related to mRNA and protein expression, and antigen-specific immune responses in cancer patients are also available, together with links to PubMed for relevant CT antigen articles.
登录
查看更多内容
影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
DOI：
10.1073/pnas.152324199
发表时间：
2002-08-20
影响因子：
11.1
作者：
Boon, K;Osório, EC;Riggins, GJ
通讯作者：
Riggins, GJ
影响因子：
14.9
作者：
Wheeler, David L.;Barrett, Tanya;Benson, Dennis A.;Bryant, Stephen H.;Canese, Kathi;Chetvernin, Vyacheslav;Church, Deanna M.;DiCuccio, Michael;Edgar, Ron;Federhen, Scott;Feolo, Michael;Geer, Lewis Y.;Helmberg, Wolfgang;Kapustin, Yuri;Khovayko, Oleg;Landsman, David;Lipman, David J.;Madden, Thomas L.;Maglott, Donna R.;Miller, Vadim;Ostell, James;Pruitt, Kim D.;Schuler, Gregory D.;Shumway, Martin;Sequeira, Edwin;Sherry, Steven T.;Sirotkin, Karl;Souvorov, Alexandre;Starchenko, Grigory;Tatusov, Roman L.;Tatusova, Tatiana A.;Wagner, Lukas;Yaschenko, Eugene
通讯作者：
Yaschenko, Eugene
影响因子：
9.5
作者：
Kumar, S;Tamura, K;Nei, M
通讯作者：
Nei, M
影响因子：
14.9
作者：
Pruitt KD;Tatusova T;Maglott DR
通讯作者：
Maglott DR