Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice.
Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice.
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DOI：
10.1186/s12890-015-0059-2
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发表时间：
2015-06-10
影响因子：
3.1
通讯作者：
Kimura H
中科院分区：
文献类型：
--
作者：
Tomoda K;Kubo K;Dairiki K;Yamaji T;Yamamoto Y;Nishii Y;Nakamura A;Yoshikawa M;Hamada K;Kimura H
慢性阻塞性肺病（COPD）中存在全身炎症。基于乳清肽的肠内饮食可减少慢性阻塞性肺病患者的炎症，但其对慢性阻塞性肺病发展的影响尚未确定。另一方面，众所周知，肠道微生物群产生的短链脂肪酸（SCFA）可以减轻小鼠模型中的支气管哮喘。患有弹性蛋白酶诱导肺气肿的小鼠被喂食 3 种饮食中的一种（对照饮食、基于乳清肽的肠内饮食或标准肠内饮食），以确定基于乳清肽的肠内饮食对肺气肿和盲肠 SCFA 的影响。基于乳清肽的肠内饮食组表现出较少的肺气肿变化；支气管肺泡灌洗液 (BALF) 中的总细胞计数显着降低；盲肠 SCFA 水平显着高于对照组或标准肠内饮食组。在这三个饮食组中，总细胞计数与盲肠总 SCFA 水平呈负相关。基于乳清肽的肠内饮食通过抑制肺部炎症来减轻弹性蛋白酶诱导的肺气肿。这可能与盲肠 SCFA 增加有关。
Systemic inflammation is present in chronic obstructive pulmonary disease (COPD). A whey peptide-based enteral diet reduce inflammation in patients with COPD, but its effect on COPD development has not been determined. On the other hand, it is known that short chain fatty acids (SCFAs), which are produced by micro-flora in the gut, attenuates bronchial asthma in mice model. Mice with elastase-induced emphysema were fed with 1 of 3 diets (control diet, whey peptide-based enteral diet, or standard enteral diet) to determine the effects of whey peptide-based enteral diet on emphysema and on cecal SCFAs. The whey peptide-based enteral diet group exhibited fewer emphysematous changes; significantly lower total cell counts in bronchoalveolar lavage fluid (BALF); and significantly higher cecal SCFA levels than either the control or standard enteral diet groups. The total cell count was inversely correlated with total cecal SCFA levels in these three diet groups. The whey peptide-based enteral diet attenuates elastase-induced emphysema through the suppression of inflammation in the lung. This may be related to the increase in cecal SCFA.
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影响因子：
10
作者：
David, GL;Koh, WP;London, SJ
通讯作者：
London, SJ
影响因子：
24.5
作者：
ROEDIGER, WEW
通讯作者：
ROEDIGER, WEW
DOI：
10.1164/rccm.200506-901oc
发表时间：
2006-02-01
影响因子：
24.7
作者：
Butler, LM;Koh, WP;London, SJ
通讯作者：
London, SJ
影响因子：
4.6
作者：
Shu, Weiguo;Lu, Min Min;Morrisey, Edward E.
通讯作者：
Morrisey, Edward E.
影响因子：
1.6
作者：
Kume, Hisae;Okazaki, Keiko;Sasaki, Hajime
通讯作者：
Sasaki, Hajime