Dynamic inversion enables external magnets to concentrate ferromagnetic rods to a central target.
Dynamic inversion enables external magnets to concentrate ferromagnetic rods to a central target.
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DOI：
10.1021/nl503654t
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发表时间：
2015-01-14
期刊：
影响因子：
10.8
通讯作者：
Shapiro B
中科院分区：
文献类型：
--
作者：
Nacev A;Weinberg IN;Stepanov PY;Kupfer S;Mair LO;Urdaneta MG;Shimoji M;Fricke ST;Shapiro B
使用体外磁体将治疗聚焦到深部组织靶点的能力仍然是磁性药物靶向的一个难以捉摸的目标。迄今为止，研究人员已经能够利用附近的磁体在体内操纵磁性纳米治疗药物，但仍然无法使用体外磁体将这些治疗方法集中到体内深处的靶点。使治疗聚焦于磁体之间的中心目标具有挑战性的因素之一是应用于麦克斯韦方程的塞缪尔·恩肖定理。这些数学公式意味着外部静态磁体不能在它们之间产生稳定的势能。我们假设，快磁脉冲可以在铁磁棒与磁场重新对准之前作用于它们。在数学上，这相当于反转恩肖定理中势能项的符号，从而使磁体之间的准静态稳定陷阱成为可能。通过体外实验，我们证明了快速成形的磁脉冲可以成功地用于产生向内指向的磁力，平均而言，这种磁力使外部磁体能够将铁磁棒集中到中心位置。
The ability to use magnets external to the body to focus therapy to deep tissue targets has remained an elusive goal in magnetic drug targeting. Researchers have hitherto been able to manipulate magnetic nanotherapeutics in vivo with nearby magnets but have remained unable to focus these therapies to targets deep within the body using magnets external to the body. One of the factors that has made focusing of therapy to central targets between magnets challenging is Samuel Earnshaw’s theorem as applied to Maxwell’s equations. These mathematical formulations imply that external static magnets cannot create a stable potential energy well between them. We posited that fast magnetic pulses could act on ferromagnetic rods before they could realign with the magnetic field. Mathematically, this is equivalent to reversing the sign of the potential energy term in Earnshaw’s theorem, thus enabling a quasi-static stable trap between magnets. With in vitro experiments, we demonstrated that quick, shaped magnetic pulses can be successfully used to create inward pointing magnetic forces that, on average, enable external magnets to concentrate ferromagnetic rods to a central location.
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影响因子：
2.2
作者：
Lübbe, AS;Alexiou, C;Bergemann, C
通讯作者：
Bergemann, C
影响因子：
4.6
作者：
Forbes, Zachary G.;Yellen, Benjamin B.;Friedman, Gary
通讯作者：
Friedman, Gary
影响因子：
2.2
作者：
Krukemeyer, Manfred G.;Krenn, Veit;Wagner, Wolfgang
通讯作者：
Wagner, Wolfgang
影响因子：
2.7
作者：
Hayden, M. E.;Haefeli, U. O.
通讯作者：
Haefeli, U. O.
DOI：
10.1073/pnas.1003388107
发表时间：
2010-08-24
影响因子：
11.1
作者：
Liu, Hao-Li;Hua, Mu-Yi;Wei, Kuo-Chen
通讯作者：
Wei, Kuo-Chen