Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis.
Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis.
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DOI：
10.1038/bjc.2017.244
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发表时间：
2017-09-05
影响因子：
8.8
通讯作者：
Salo T
中科院分区：
文献类型：
--
作者：
Almangush A;Heikkinen I;Mäkitie AA;Coletta RD;Läärä E;Leivo I;Salo T
确定口腔舌鳞癌（OTSCC）的预后生物标志物对于更好地预测肿瘤行为和指导治疗计划具有重要意义。在这里，我们总结了关于OTSCC的免疫组织化学预后生物标志物的现有证据。使用Scopus、Ovid Medline、Web of Science和Cochrane Library等数据库进行系统检索。检索1985 - 2015年间所有探讨免疫组织化学生物标志物在OTSCC预后意义的研究。对于最常评估的五种生物标志物，进行了对总生存率的随机效应荟萃分析，包括那些提供必要统计结果的研究。在过去的三十年中，共有174项研究被发现，其中184项生物标志物被评估为OTSCC的预测。最常评估的五种生物标志物是p53、Ki-67、p16、vegf和cyclin D1。在荟萃分析中，对OTSCC的预后能力最有希望的结果是cyclin D1。对于VEGF A和C的研究，结果是模棱两可的，但单独的VEGF A的汇总分析显示它是OTSCC的一个有用的预后指标。没有足够的证据支持p53、Ki-67和p16作为OTSCC的预后生物标志物。已发表研究的质量限制（例如，小队列，缺乏对REMARK指南的遵守）是普遍存在的。许多生物标志物已被认为是OTSCC的有用预测指标，但原始研究的实施和报告的质量总体上令人不满意，因此无法得出可靠的结论。两种生物标志物（VEGF-A和cyclin D1）的价值应按照REMARK指南在多中心研究环境中进行验证。
Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results. A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread. Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines.
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影响因子：
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作者：
Ferrari D;Codecà C;Fiore J;Moneghini L;Bosari S;Foa P
通讯作者：
Foa P
DOI：
10.1002/hed.24589
发表时间：
2017-02-01
影响因子：
2.9
作者：
Ng, Jia Hui;Iyer, N. Gopalakrishna;Edgren, Gustaf
通讯作者：
Edgren, Gustaf
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
13.6
作者：
Greenland S;Senn SJ;Rothman KJ;Carlin JB;Poole C;Goodman SN;Altman DG
通讯作者：
Altman DG
DOI：
10.1155/2001/780576
发表时间：
2001
期刊：
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology
影响因子：
--
作者：
Hannen EJ;van der Laak JA;Kerstens HM;Cuijpers VM;Hanselaar AG;Manni JJ;de Wilde PC
通讯作者：
de Wilde PC