Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.
Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.
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DOI：
10.1002/jnr.24100
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发表时间：
2018-04
影响因子：
4.2
通讯作者：
Vavilala MS
中科院分区：
文献类型：
--
作者：
Chaikittisilpa N;Krishnamoorthy V;Lele AV;Qiu Q;Vavilala MS
收缩功能障碍最近被描述为创伤性脑损伤（TBI）后，全身性炎症可能是一个促进机制。我们的目的是：1)检查TBI后早期全身性炎症反应综合征（SIRS）与收缩期心功能障碍之间的关系；2)描述住院第一周SIRS标准、心功能和血流动力学参数的纵向变化。我们对一项前瞻性队列研究进行了二次分析，该研究检查了32例中重度孤立TBI患者的心功能（在住院第一天和住院第一周连续使用经胸超声心动图），并量化了入院和每日SIRS对损伤的反应。我们确定了入院时SIRS与TBI后收缩功能障碍的关系。多变量分析显示，7例（21%）患者入院时出现SIRS，并与收缩功能障碍相关（RR 4.01; 95% 1.16-13.79, p = 0.028）。SIRS标准和收缩期心功能在住院的第一周得到改善。总之，早期SIRS在中重度TBI患者中很常见，入院时是否存在SIRS标准与TBI后的收缩期心功能障碍有关。
Systolic dysfunction was recently described following traumatic brain injury (TBI) and systemic inflammation may be a contributing mechanism. Our aims were to: 1) Examine the association between the early systemic inflammatory response syndrome (SIRS) and systolic cardiac dysfunction following TBI and 2) Describe the longitudinal change in SIRS criteria, cardiac function, and hemodynamic parameters during the first week of hospitalization. We used a secondary analysis of a prospective cohort study examining cardiac function (with transthoracic echocardiography on the first day and serially over the first week of hospitalization) in 32 moderate-severe isolated TBI patients, and quantified the admission and daily SIRS response to injury. We determined the association of admission SIRS and systolic dysfunction following TBI. Admission SIRS was present in 7 (21%) of patients and was associated with systolic dysfunction on multivariable analysis (RR 4.01; 95% 1.16–13.79, p = 0.028). Both SIRS criteria and systolic cardiac function improved over the first week of hospitalization. In conclusion, early SIRS is common among patients with moderate-severe TBI and the presence of SIRS criteria on admission is associated with systolic cardiac dysfunction following TBI.
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影响因子：
8.3
作者：
Boehme AK;Kapoor N;Albright KC;Lyerly MJ;Rawal PV;Bavarsad Shahripour R;Alvi M;Houston JT;Sisson A;Beasley TM;Alexandrov AW;Alexandrov AV;Miller DW
通讯作者：
Miller DW
影响因子：
3.8
作者：
ICHIJO, T;KATAFUCHI, T;HORI, T
通讯作者：
HORI, T
影响因子：
8.3
作者：
Audebert, HJ;Rott, MM;Haberl, RL
通讯作者：
Haberl, RL
DOI：
10.1186/cc1822
发表时间：
2002-12
期刊：
Critical care (London, England)
影响因子：
--
作者：
Court O;Kumar A;Parrillo JE;Kumar A
通讯作者：
Kumar A
影响因子：
8.3
作者：
Elrifai, AM;Bailes, JE;Brillman, J
通讯作者：
Brillman, J