Treatment and Prevention of (Early) Osteoarthritis Using Articular Cartilage Repair-Fact or Fiction? A Systematic Review.
Treatment and Prevention of (Early) Osteoarthritis Using Articular Cartilage Repair-Fact or Fiction? A Systematic Review.
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DOI：
10.1177/1947603513486560
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发表时间：
2013-07
期刊：
影响因子：
2.8
通讯作者：
Saris DB
中科院分区：
文献类型：
--
作者：
de Windt TS;Vonk LA;Brittberg M;Saris DB
早期骨关节炎（OA）越来越多的患者希望保持活动，而不接受保守治疗或关节置换术的限制。本系统综述的目的是评估使用关节软骨修复技术治疗早期OA患者的现有证据。在EMBASE、MEDLINE和Cochrane协作网中进行系统检索。对文章进行相关性筛选和质量评价。9篇方法学质量普遍较低的文章（平均Coleman评分58分），共纳入502例患者（平均年龄36-57岁）。在报告中，早期OA的放射学和临床标准都被应用。在本综述纳入的所有患者中，75%的患者接受了自体软骨细胞植入治疗。9年的短期临床结果良好。失败率从8%到27.3%不等。全膝关节置换术的转化率为2.5% ~ 6.5%。虽然需要对这类患者进行长期随访的（随机对照）试验，但文献表明自体软骨细胞植入可以提供良好的中短期临床结果，并延迟全膝关节置换术的需要。早期OA的标准化标准的使用和长期随访的（随机）试验的实施可能会进一步扩大关节软骨修复的研究领域，以治疗（早期）OA患者。
Early osteoarthritis (OA) is increasingly being recognized in patients who wish to remain active while not accepting the limitations of conservative treatment or joint replacement. The aim of this systematic review was to evaluate the existing evidence for treatment of patients with early OA using articular cartilage repair techniques. A systematic search was performed in EMBASE, MEDLINE, and the Cochrane collaboration. Articles were screened for relevance and appraised for quality. Nine articles of generally low methodological quality (mean Coleman score 58) including a total of 502 patients (mean age range = 36-57 years) could be included. In the reports, both radiological and clinical criteria for early OA were applied. Of all patients included in this review, 75% were treated with autologous chondrocyte implantation. Good short-term clinical outcome up to 9 years was shown. Failure rates varied from 8% to 27.3%. The conversion to total knee arthroplasty rate was 2.5% to 6.5%. Although a (randomized controlled) trial in this patient category with long-term follow-up is needed, the literature suggests autologous chondrocyte implantation could provide good short- to mid-term clinical outcome and delay the need for total knee arthroplasty. The use of standardized criteria for early OA and implementation of (randomized) trials with long-term follow-up may allow for further expansion of the research field in articular cartilage repair to the challenging population with (early) OA.
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影响因子：
3.8
作者：
Filardo, Giuseppe;Kon, Elizaveta;Marcacci, Maurilio
通讯作者：
Marcacci, Maurilio
影响因子：
4.2
作者：
Goertz, Simon;De Young, Allison J.;Bugbee, William D.
通讯作者：
Bugbee, William D.
影响因子：
3.8
作者：
Heijink, Andras;Gomoll, Andreas H.;Madry, Henning;Drobnic, Matej;Filardo, Giuseppe;Espregueira-Mendes, Joao;Van Dijk, C. Niek
通讯作者：
Van Dijk, C. Niek
影响因子：
1.9
作者：
Bauer, S.;Khan, R. J. K.;Wood, D. J.
通讯作者：
Wood, D. J.
DOI：
10.2106/00004623-199302000-00006
发表时间：
1993-02-01
影响因子：
5.3
作者：
COVENTRY, MB;ILSTRUP, DM;WALLRICHS, SL
通讯作者：
WALLRICHS, SL