Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston's organ of the fruit fly.
Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston's organ of the fruit fly.
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DOI：
10.3389/fphys.2014.00179
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发表时间：
2014
影响因子：
4
通讯作者：
Kamikouchi A
中科院分区：
文献类型：
--
作者：
Matsuo E;Yamada D;Ishikawa Y;Asai T;Ishimoto H;Kamikouchi A
果蝇黑腹果蝇对声音、重力和风做出行为反应。位于触角底部的约翰斯顿器官(JO)在果蝇体内作为感觉器官来检测这些机械感觉刺激。在JO的五个解剖学定义的感觉神经元亚群中，A和B亚群探测声音振动，C和E亚群对静态偏转做出反应，如重力和风。然而，D亚群JO神经元的功能仍不清楚。在这项研究中，我们使用分子遗传学的方法来探索D-JO亚群神经元的生理特性。天线接收器的振动和静态偏转都激活了D-JO亚群神经元。这一发现清楚地表明，D亚群JO神经元的投射靶--触角机械感觉和运动中心(AMMC)中的D区是苍蝇脑中触角振动和偏转的主要中枢。我们在解剖学上确定了D JO亚群下游的两种中间神经元：AMMC局部神经元(AMMC LNS)和AMMC D1神经元。AMMC LN是局部神经元，其投射局限在AMMC内，连接B区和D区。另一方面，AMMC D1神经元既有AMMC内的局部树突分支，也有向胸神经节的下行投射，这表明AMMC D1神经元可能将AMMC-D JO亚群检测到的触角运动信息直接从AMMC传递到胸部。总而言之，这些发现为JO及其大脑目标如何编码果蝇触角复杂运动的信息提供了神经基础。
The fruit fly Drosophila melanogaster responds behaviorally to sound, gravity, and wind. Johnston's organ (JO) at the antennal base serves as a sensory organ in the fruit fly to detect these mechanosensory stimuli. Among the five anatomically defined subgroups of sensory neurons in JO, subgroups A and B detect sound vibrations and subgroups C and E respond to static deflections, such as gravity and wind. The functions of subgroup-D JO neurons, however, remain unknown. In this study, we used molecular-genetic methods to explore the physiologic properties of subgroup-D JO neurons. Both vibrations and static deflection of the antennal receiver activated subgroup-D JO neurons. This finding clearly revealed that zone D in the antennal mechanosensory and motor center (AMMC), the projection target of subgroup-D JO neurons, is a primary center for antennal vibrations and deflection in the fly brain. We anatomically identified two types of interneurons downstream of subgroup-D JO neurons, AMMC local neurons (AMMC LNs), and AMMC D1 neurons. AMMC LNs are local neurons whose projections are confined within the AMMC, connecting zones B and D. On the other hand, AMMC D1 neurons have both local dendritic arborizations within the AMMC and descending projections to the thoracic ganglia, suggesting that AMMC D1 neurons are likely to relay information of the antennal movement detected by subgroup-D JO neurons from the AMMC directly to the thorax. Together, these findings provide a neural basis for how JO and its brain targets encode information of complex movements of the fruit fly antenna.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
1.5
作者：
Hayashi, S;Ito, K;Goto, S
通讯作者：
Goto, S
影响因子：
3.3
作者：
Kavlie, Ryan G.;Kernan, Maurice J.;Eberl, Daniel F.
通讯作者：
Eberl, Daniel F.
DOI：
10.1007/bf02179499
发表时间：
1995-05-01
期刊：
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY
影响因子：
--
作者：
ITO, K;URBAN, J;TECHNAU, GM
通讯作者：
TECHNAU, GM
影响因子：
14.8
作者：
Kamikouchi, Azusa;Wiek, Robert;Fiala, Andre
通讯作者：
Fiala, Andre