Serum S100B: a potential biomarker for suicidality in adolescents?
Serum S100B: a potential biomarker for suicidality in adolescents?
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DOI：
10.1371/journal.pone.0011089
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发表时间：
2010-06-14
期刊：
影响因子：
3.7
通讯作者：
Janigro D
中科院分区：
文献类型：
--
作者：
Falcone T;Fazio V;Lee C;Simon B;Franco K;Marchi N;Janigro D
研究表明，患有抑郁症或精神分裂症的患者通常会在血液中检测到免疫变化。其他人报告说，自杀患者的炎症、小胶质细胞增多症和血脑屏障(BBB)之间可能存在联系。血清S100B是血脑屏障功能的标志物，常用于脑血管壁功能的研究。测定了40例急性精神病青少年、24例心境障碍青少年和20例健康青少年血清S100B水平。所有患者均按DSM-IV诊断标准进行诊断。我们使用简明儿童精神病学评定量表(BPRS-C)中的自杀意念来评估自杀意念。血清S100B水平显著升高(p<；0.05)，且与精神病或心境障碍患者的自杀意念严重程度相关，与精神疾病诊断无关。自杀倾向评分为1~4(低自杀倾向)的患者血清S100B均值为0.152+/−0.020 ng/mL(n = 34)，而自杀倾向评分为5~7(高自杀倾向)的患者血清S100B均值为0.354+/−0.044 ng/mL(n = 30)。这一差异具有统计学意义(p<；0.05)。我们的数据支持使用S100B作为辅助生物标记物来评估心境障碍或精神分裂症患者的自杀风险。
Studies have shown that patients suffering from depression or schizophrenia often have immunological alterations that can be detected in the blood. Others reported a possible link between inflammation, a microgliosis and the blood-brain barrier (BBB) in suicidal patients. Serum S100B is a marker of BBB function commonly used to study cerebrovascular wall function. We measured levels of S100B in serum of 40 adolescents with acute psychosis, 24 adolescents with mood disorders and 20 healthy controls. Patients were diagnosed according to DSM-IV TR criteria. We evaluated suicidal ideation using the suicidality subscale of the Brief Psychiatric Rating Scale for Children (BPRS-C). Serum S100B levels were significantly higher (p<0.05) and correlated to severity of suicidal ideation in patients with psychosis or mood disorders, independent of psychiatric diagnosis. Patients with a BPRS-C suicidality subscores of 1–4 (low suicidality) had mean serum S100B values +/− SEM of 0.152+/−0.020 ng/mL (n = 34) compared to those with BPRS-C suicidality subscores of 5–7 (high suicidality) with a mean of 0.354+/−0.044 ng/mL (n = 30). This difference was statistically significant (p<0.05). Our data support the use of S100B as an adjunctive biomarker to assess suicidal risk in patients with mood disorders or schizophrenia.
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影响因子：
3.7
作者：
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通讯作者：
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DOI：
10.1089/104454601750143500
发表时间：
2001-03-01
影响因子：
1.9
作者：
Hughes, CW;Rintelmann, J;MacCabe, N
通讯作者：
MacCabe, N