Hidden memories: frontline memory T cells and early pathogen interception.
Hidden memories: frontline memory T cells and early pathogen interception.
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DOI：
10.4049/jimmunol.1102695
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发表时间：
2012-06-15
期刊：
影响因子：
--
通讯作者：
Picker LJ
中科院分区：
文献类型：
--
作者：
Masopust D;Picker LJ
免疫记忆反映了宿主对与特定病原体的再次遭遇比第一次遭遇更有效地应答的能力，并且当疫苗模拟第一次遭遇时，免疫记忆构成了疫苗效力的基础。对于T细胞来说，记忆通常等同于回忆反应，即基于次级淋巴组织（VIM）的（中央）记忆T细胞对病原体暴露做出反应的能力，其病原体特异性效应细胞的产生和感染部位递送比在幼稚宿主中观察到的更快和更高。然而，越来越多的证据支持一种根本不同类型的T细胞记忆，其中预先定位在潜在病原体入侵部位或从血液和边缘池快速动员到这些部位的分化的长寿命效应记忆T细胞（TEM）在感染数小时内拦截并潜在地控制/消除病原体。在这里，我们回顾了这种“隐藏”的T细胞记忆的证据，以及它对疫苗开发的影响。
Immunologic memory reflects the ability of a host to more effectively respond to a re-encounter with a particular pathogen than the first encounter, and when a vaccine mimics the first encounter, comprises the basis of vaccine efficacy. For T cells, memory is often equated with the anamnestic response, the ability of secondary lymphoid tissue (SLT)-based(central) memory T cells to respond to pathogen exposure with a more rapid and higher magnitude production and infection-site delivery of pathogen-specific effector cells than observed in naïve hosts. However, increasing evidence supports a fundamentally different kind of T cell memory in which differentiated, long-lived effector memory T cells (TEM), pre-positioned in sites of potential pathogen invasion or rapidly mobilized to such sites from blood and marginated pools, intercept and potentially control/eliminate pathogen within hours of infection. Here, we review the evidence for this “hidden” T cell memory, and its implication for vaccine development.
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DOI：
10.1084/jem.20052237
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jabbari A;Harty JT
通讯作者：
Harty JT
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
15.3
作者：
El-Asady, R;Yuan, RW;Hadley, GA
通讯作者：
Hadley, GA
影响因子：
64.8
作者：
Champagne, P;Ogg, GS;Pantaleo, G
通讯作者：
Pantaleo, G
影响因子：
64.8
作者：
Hansen, Scott G.;Ford, Julia C.;Lewis, Matthew S.;Ventura, Abigail B.;Hughes, Colette M.;Coyne-Johnson, Lia;Whizin, Nathan;Oswald, Kelli;Shoemaker, Rebecca;Swanson, Tonya;Legasse, Alfred W.;Chiuchiolo, Maria J.;Parks, Christopher L.;Axthelm, Michael K.;Nelson, Jay A.;Jarvis, Michael A.;Piatak, Michael, Jr.;Lifson, Jeffrey D.;Picker, Louis J.
通讯作者：
Picker, Louis J.