Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.
Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.
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DOI：
10.3892/or.2015.3838
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发表时间：
2015-05
期刊：
影响因子：
4.2
通讯作者：
Nakamura S
中科院分区：
文献类型：
--
作者：
Jinno T;Kawano S;Maruse Y;Matsubara R;Goto Y;Sakamoto T;Hashiguchi Y;Kaneko N;Tanaka H;Kitamura R;Toyoshima T;Jinno A;Moriyama M;Oobu K;Kiyoshima T;Nakamura S
最近的研究表明，癌细胞会因慢性炎症而恶化。本研究采用免疫组化方法检测口腔鳞状细胞癌（OSCC）组织中白细胞介素-6（IL-6）的表达，探讨IL-6表达与肿瘤进展、化疗耐药及预后的关系。对78例原发性口腔鳞癌患者进行IL-6免疫组化染色分析。计算这些标记指数（LI），并与口腔鳞癌患者的临床病理特征和预后进行评估。将患者分为三组：阴性组= LI <5%;低IL-6组= LI <30%;高IL-6组= LI ≥ 30%。阴性表达组24例，低表达组22例，高表达组32例。在IL-6高表达组中，几乎所有的癌细胞中也检测到IL-6受体（IL-6 R）、磷酸化信号转导子和转录激活子3（p-STAT 3）。高表达组的颈淋巴结或远处转移率显著高于阴性组和低表达组。此外，高表达组对术前放化疗的反应明显较差，预后比阴性和低表达组更差。有趣的是，IL-6、IL-6 R和p-STAT 3在高表达组中所有对放化疗反应差的患者的残留癌细胞中均表达。提示IL-6信号通路可能参与了口腔鳞癌的进展和治疗抵抗，IL-6在口腔鳞癌细胞中的表达可能是口腔鳞癌放化疗效果差和预后不良的预测因子。
Recent studies have revealed that cancer cells are exacerbated by chronic inflammation. The present study examined the immunohistochemical expression for interleukin-6 (IL-6), a pleiotropic inflammatory cytokine, in oral squamous cell carcinoma (OSCC) to elucidate the association of IL-6 expression with tumor progression, chemoresistance and prognosis. Seventy-eight patients with primary OSCC were analyzed by immunohistochemical staining for IL-6. These labeling indexes (LIs) were calculated and evaluated in association with the clinicopathologic characteristics and prognosis in the OSCC patients. The patients were divided into three groups as follows: negative group = LI <5%; low IL-6 group = 5% ≤ LI <30%; high IL-6 group = LI ≥30%. The patient numbers of the negative, low and high expression groups were 24, 22 and 32, respectively. In the high IL-6 expression group, IL-6 receptor (IL-6R), phospho-signal tranducer and activator of transcription 3 (p-STAT3) were also detected in almost all the cancer cells. The prevalence of the cervical lymph node or the distant metastasis in the high expression group was significantly higher than those in the negative and low expression groups. Furthermore, the high expression group had a significantly poorer tumor response to the preoperative chemoradiotherapy and a more unfavourable prognosis than the negative and the low expression groups. Interestingly, IL-6, IL-6R and p-STAT3 were expressed in the residual cancer cells of all the patients in the high expression group with poor response to chemoradiotherapy. These results suggested that IL-6 signaling possibly is involved in the progression and treatment-resistance of OSCC and IL-6 expression in cancer cells could be a useful predictive factor of poor response to chemoradiotherapy and unfavorable prognosis.
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影响因子：
3.8
作者：
Lane D;Matte I;Rancourt C;Piché A
通讯作者：
Piché A
影响因子：
4.8
作者：
Kirita, T;Ohgi, K;Sugimura, M
通讯作者：
Sugimura, M
STAT3 信号通路的沉默可逆转人卵巢癌细胞固有的和诱导的化疗耐药性。
DOI：
10.1016/j.bbrc.2013.04.087
发表时间：
2013-05-31
影响因子：
3.1
作者：
Han, Zhiqiang;Feng, Jing;Gao, Qinglei
通讯作者：
Gao, Qinglei
DOI：
10.1002/hed.10004
发表时间：
2002-02-01
影响因子：
2.9
作者：
Funk, GF;Karnell, LH;Hoffman, HT
通讯作者：
Hoffman, HT
影响因子：
6.4
作者：
Chakravarti, Nitin;Myers, Jeffrey N.;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.