Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI).
Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI).
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使用扩散光谱成像（DSI）检测与退化性宫颈脊髓病有关的大脑重组。
DOI：
10.1016/j.jocn.2021.01.011
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Ellingson BM
中科院分区：
文献类型：
--
作者：
Wang C;Holly LT;Oughourlian T;Yao J;Raymond C;Salamon N;Ellingson BM
退行性颈髓病（DCM）是一种导致老年患者严重身体残疾的脊髓疾病。虽然大多数DCM研究集中在脊髓，但可能会发生广泛的大脑重组以弥补功能障碍。这项观察性研究使用弥散光谱成像（DSI）检查与神经功能缺损相关的脑白色物质重组（由改良日本骨科协会（mJOA）测量）和颈部残疾指数（NDI）评分测量的颈部残疾严重程度。颈椎病（CS）队列共纳入47例患者：38例DCM患者（平均mJOA=14.6，平均NDI=12.0），9例无神经系统症状的脊髓压迫患者（mJOA=18，平均NDI=7.0）。28例健康志愿者作为对照组。与HC相比，在患者的大部分脑中观察到较低的广义各向异性分数（GFA）（p<0.05）。与躯体感觉功能相关的纤维通路，如胼胝体和放射冠，与HC相比，患者的定量各向异性（QA）增加。相关性分析进一步表明，结构连接性增强，以补偿感觉运动区域内的神经功能障碍，其中后放射冠等纤维的NQA值与mJOA呈负相关（p=0.0020，R2=0.2935），与NDI评分呈正相关（p=0.0164，R2=0.1889）。总之，这些结果表明，DCM和神经学上无症状的脊髓压迫患者倾向于在大脑内进行长期重组，特别是在那些负责感知和整合感觉信息、运动调节和疼痛调制的区域。
Degenerative Cervical Myelopathy (DCM) is a spinal cord disorder that causes significant physical disabilities in older patients. While most DCM research focuses on the spinal cord, widespread reorganization of the brain may occur to compensate for functional impairment. This observational study used diffusion spectrum imaging (DSI) to examine reorganization of cerebral white matter associated with neurological impairment as measured by the modified Japanese Orthopedic Association (mJOA), and severity of neck disability as measured by the Neck Disability Index (NDI) score. A total of 47 patients were included in the cervical spondylosis (CS) cohort: 38 patients with DCM (mean mJOA=14.6, and mean NDI=12.0), and 9 neurologically asymptomatic patients with spinal cord compression (mJOA=18, and mean NDI=7.0). 28 healthy volunteers (HCs) served as the control group. Lower generalized fractional anisotropy (GFA) was observed throughout much of the brain in patients compared to HCs (p<0.05). Fiber pathways associated with somatosensory functions, such as the corpus callosum and corona radiata, showed increased quantitative anisotropy (QA) in patients compared to HCs. Correlation analyses further suggested that structural connectivity was enhanced to compensate for neurological dysfunction within sensorimotor regions, where fibers such as the posterior corona radiata had NQA values that were negatively associated with mJOA (p=0.0020, R2=0.2935) and positively associated with NDI score (p=0.0164, R2=0.1889). Altogether, these results suggest that DCM and neurologically asymptomatic spinal cord compression patients tend to have long-term reorganization within the brain, particularly in those regions responsible for the perception and integration of sensory information, motor regulation, and pain modulation.
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影响因子：
4.2
作者：
Curt, A;Bruehlmeier, M;Dietz, V
通讯作者：
Dietz, V
影响因子：
2.8
作者：
Ellingson, Benjamin M.;Salamon, Noriko;Holly, Langston T.
通讯作者：
Holly, Langston T.
扩散张量成像可以预测轻度至中度颈椎脊髓病的功能障碍。
DOI：
10.1016/j.spinee.2014.02.027
发表时间：
2014-11-01
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Ellingson BM;Salamon N;Grinstead JW;Holly LT
通讯作者：
Holly LT
影响因子：
5.3
作者：
Ramu, Jaivijay;Bockhorst, Kurt H.;Narayana, Ponnada A.
通讯作者：
Narayana, Ponnada A.
影响因子：
4.2
作者：
Ramu, Jaivijay;Bockhorst, Kurt H.;Narayana, Ponnada A.
通讯作者：
Narayana, Ponnada A.