A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer.
A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer.
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DOI：
10.1016/j.eururo.2022.05.008
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发表时间：
2023-04
期刊：
影响因子：
23.4
通讯作者：
Mucci, Lorelei A.
中科院分区：
文献类型：
--
作者：
Plym, Anna;Zhang, Yiwen;Stopsack, Konrad H.;Delcoigne, Benedicte;Wiklund, Fredrik;Haiman, Christopher;Kenfield, Stacey A.;Kibel, Adam S.;Giovannucci, Edward;Penney, Kathryn L.;Mucci, Lorelei A.
前列腺癌是最具遗传性的癌症。有必要确定由于遗传因素导致前列腺癌风险增加的男性可能的可改变因素。研究前列腺癌遗传风险增加的男性是否可以通过坚持健康的生活方式来抵消患病或疾病进展的风险。我们在卫生专业人员随访研究（1993-2019）和医生健康研究（1983-2010）中前瞻性随访了12411名基因型男性。采用多基因风险评分（PRS）对前列腺癌的遗传风险进行量化。健康的生活方式是指健康的体重、剧烈的体育活动、不吸烟和健康的饮食。总体和致死性前列腺癌（转移性疾病/前列腺癌特异性死亡），使用估计危险比（hr）和终生风险的时间-事件分析进行分析。在27年的随访中，观察到3,005例总体前列腺癌和435例致死性前列腺癌事件。PRS不仅可以对总体前列腺癌进行风险分层，还可以对致命疾病进行风险分层，在最高和最低四分位数中，男性之间的差异为4倍（HR, 4.32; 95% CI, 3.16-5.89）。在PRS最高四分位数的男性中，与不健康的生活方式相比，坚持健康的生活方式与致命性前列腺癌的发病率降低相关（HR, 0.55; 95% CI, 0.36-0.86），在健康人群中转化为1.6% (95% CI, 0.8-3.1%)，在不健康人群中转化为5.3% （95% CI, 3.6-7.8%）。坚持健康的生活方式与降低患前列腺癌的风险无关。我们的研究结果表明，前列腺癌的遗传易感性并不是不良癌症预后的决定性因素。保持健康的生活方式可能提供一种抵消致命前列腺癌遗传风险的方法。这项研究调查了前列腺癌的遗传风险是否可以通过健康的生活方式来降低，包括健康的体重、定期锻炼、不吸烟和健康的饮食。我们观察到，在遗传风险最高的男性中，坚持健康的生活方式可以降低转移性疾病和前列腺癌死亡的风险。我们的结论是，前列腺癌遗传风险高的男性可能会从坚持健康的生活方式中受益。
Prostate cancer is the most heritable cancer. There is a need to identify possible modifiable factors for men at increased risk of prostate cancer due to genetic factors. To examine whether men at increased genetic risk of prostate cancer can offset their risk of disease or disease progression by adhering to a healthy lifestyle. We prospectively followed 12,411 genotyped men in the Health Professionals Follow-up Study (1993–2019) and the Physicians’ Health Study (1983–2010). Genetic risk of prostate cancer was quantified using a polygenic risk score (PRS). A healthy lifestyle was defined by healthy weight, vigorous physical activity, not smoking, and a healthy diet. Overall and lethal prostate cancer (metastatic disease/prostate cancer-specific death), analyzed using time-to-event analyses estimating hazard ratios (HRs) and lifetime risks. During 27 yr of follow-up, 3,005 overall prostate cancer and 435 lethal prostate cancer events were observed. The PRS enabled risk stratification not only for overall prostate cancer, but also for lethal disease with a four-fold difference between men in the highest and the lowest quartiles (HR, 4.32; 95% CI, 3.16–5.89). Among men in the highest PRS quartile, adhering to a healthy lifestyle was associated with a decreased rate of lethal prostate cancer (HR, 0.55; 95% CI, 0.36–0.86) compared with having an unhealthy lifestyle, translating to a lifetime risk of 1.6% (95% CI, 0.8–3.1%) among the healthy and 5.3% (95% CI, 3.6–7.8%) among the unhealthy. Adhering to a healthy lifestyle was not associated with a decreased risk of overall prostate cancer. Our findings suggest that a genetic predisposition for prostate cancer is not deterministic for a poor cancer outcome. Maintaining a healthy lifestyle may provide a way to offset the genetic risk of lethal prostate cancer. This study examined whether the genetic risk of prostate cancer can be attenuated by a healthy lifestyle including a healthy weight, regular exercise, not smoking, and a healthy diet. We observed that adherence to a healthy lifestyle reduced the risk of metastatic disease and prostate cancer death among men at the highest genetic risk. We conclude that men at a high genetic risk of prostate cancer may benefit from adhering to a healthy lifestyle.
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影响因子：
8.8
作者：
Rohrmann, S.;Linseisen, J.;Allen, N.;Bueno-de-Mesquita, H. B.;Johnsen, N. F.;Tjonneland, A.;Overvad, K.;Kaaks, R.;Teucher, B.;Boeing, H.;Pischon, T.;Lagiou, P.;Trichopoulou, A.;Trichopoulos, D.;Palli, D.;Krogh, Vittorio;Tunnino, R.;Ricceri, F.;Argueelles Suarez, M. V.;Agudo, A.;Sanchez, M-J;Chirlaque, M-D;Barricarte, A.;Larranaga, N.;Boshuizen, H.;van Kranen, H. J.;Stettin, P.;Johansson, M.;Bjartell, A.;Ulmert, D.;Khaw, K-T;Wareham, N. J.;Ferrari, Pietro;Romieux, I.;Gunter, M. J. R.;Riboli, Elio;Key, T. J.
通讯作者：
Key, T. J.
DOI：
10.1056/nejmoa1605086
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Khera AV;Emdin CA;Drake I;Natarajan P;Bick AG;Cook NR;Chasman DI;Baber U;Mehran R;Rader DJ;Fuster V;Boerwinkle E;Melander O;Orho-Melander M;Ridker PM;Kathiresan S
通讯作者：
Kathiresan S
影响因子：
3.7
作者：
Lindstrom, Sara;Loomis, Stephanie;Kraft, Peter
通讯作者：
Kraft, Peter
影响因子：
168.9
作者：
RIMM, EB;GIOVANNUCCI, EL;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
跨务基因组全基因组关联的前列腺癌荟萃分析确定了新的敏感性基因座并告知遗传风险预测。
影响因子：
30.8
作者：
Conti DV;Darst BF;Moss LC;Saunders EJ;Sheng X;Chou A;Schumacher FR;Olama AAA;Benlloch S;Dadaev T;Brook MN;Sahimi A;Hoffmann TJ;Takahashi A;Matsuda K;Momozawa Y;Fujita M;Muir K;Lophatananon A;Wan P;Le Marchand L;Wilkens LR;Stevens VL;Gapstur SM;Carter BD;Schleutker J;Tammela TLJ;Sipeky C;Auvinen A;Giles GG;Southey MC;MacInnis RJ;Cybulski C;Wokołorczyk D;Lubiński J;Neal DE;Donovan JL;Hamdy FC;Martin RM;Nordestgaard BG;Nielsen SF;Weischer M;Bojesen SE;Røder MA;Iversen P;Batra J;Chambers S;Moya L;Horvath L;Clements JA;Tilley W;Risbridger GP;Gronberg H;Aly M;Szulkin R;Eklund M;Nordström T;Pashayan N;Dunning AM;Ghoussaini M;Travis RC;Key TJ;Riboli E;Park JY;Sellers TA;Lin HY;Albanes D;Weinstein SJ;Mucci LA;Giovannucci E;Lindstrom S;Kraft P;Hunter DJ;Penney KL;Turman C;Tangen CM;Goodman PJ;Thompson IM Jr;Hamilton RJ;Fleshner NE;Finelli A;Parent MÉ;Stanford JL;Ostrander EA;Geybels MS;Koutros S;Freeman LEB;Stampfer M;Wolk A;Håkansson N;Andriole GL;Hoover RN;Machiela MJ;Sørensen KD;Borre M;Blot WJ;Zheng W;Yeboah ED;Mensah JE;Lu YJ;Zhang HW;Feng N;Mao X;Wu Y;Zhao SC;Sun Z;Thibodeau SN;McDonnell SK;Schaid DJ;West CML;Burnet N;Barnett G;Maier C;Schnoeller T;Luedeke M;Kibel AS;Drake BF;Cussenot O;Cancel-Tassin G;Menegaux F;Truong T;Koudou YA;John EM;Grindedal EM;Maehle L;Khaw KT;Ingles SA;Stern MC;Vega A;Gómez-Caamaño A;Fachal L;Rosenstein BS;Kerns SL;Ostrer H;Teixeira MR;Paulo P;Brandão A;Watya S;Lubwama A;Bensen JT;Fontham ETH;Mohler J;Taylor JA;Kogevinas M;Llorca J;Castaño-Vinyals G;Cannon-Albright L;Teerlink CC;Huff CD;Strom SS;Multigner L;Blanchet P;Brureau L;Kaneva R;Slavov C;Mitev V;Leach RJ;Weaver B;Brenner H;Cuk K;Holleczek B;Saum KU;Klein EA;Hsing AW;Kittles RA;Murphy AB;Logothetis CJ;Kim J;Neuhausen SL;Steele L;Ding YC;Isaacs WB;Nemesure B;Hennis AJM;Carpten J;Pandha H;Michael A;De Ruyck K;De Meerleer G;Ost P;Xu J;Razack A;Lim J;Teo SH;Newcomb LF;Lin DW;Fowke JH;Neslund-Dudas C;Rybicki BA;Gamulin M;Lessel D;Kulis T;Usmani N;Singhal S;Parliament M;Claessens F;Joniau S;Van den Broeck T;Gago-Dominguez M;Castelao JE;Martinez ME;Larkin S;Townsend PA;Aukim-Hastie C;Bush WS;Aldrich MC;Crawford DC;Srivastava S;Cullen JC;Petrovics G;Casey G;Roobol MJ;Jenster G;van Schaik RHN;Hu JJ;Sanderson M;Varma R;McKean-Cowdin R;Torres M;Mancuso N;Berndt SI;Van Den Eeden SK;Easton DF;Chanock SJ;Cook MB;Wiklund F;Nakagawa H;Witte JS;Eeles RA;Kote-Jarai Z;Haiman CA
通讯作者：
Haiman CA