Collapsibility of lung volume by paired inspiratory and expiratory CT scans: correlations with lung function and mean lung density.
Collapsibility of lung volume by paired inspiratory and expiratory CT scans: correlations with lung function and mean lung density.
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DOI：
10.1016/j.acra.2009.11.004
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发表时间：
2010-04
影响因子：
4.8
通讯作者：
Washko, George R.
中科院分区：
文献类型：
--
作者：
Yamashiro, Tsuneo;Matsuoka, Shin;Bartholmai, Brian J.;Estepar, Raul San Jose;Ross, James C.;Diaz, Alejandro;Murayama, Sadayuki;Silverman, Edwin K.;Hatabu, Hiroto;Washko, George R.
关键词：
目的探讨慢性阻塞性肺疾病(COPD)患者吸气/呼气计算机体层摄影(CT)肺容量(LV)测量与肺功能、肺气肿CT测量之间的关系。46名吸烟者(20名女性和26名男性；年龄范围46-81岁)登记在NHLBI肺组织研究联盟中，在充分吸气和呼气时进行了PFT和胸部CT检查。用开源软件自动测量吸气相和呼气相LV，计算出LV的呼气/吸气比值(E/I)。测定平均肺密度(MLD)和低密度肺密度(LAA%；−950HU)。采用Spearman等级相关检验评价LV测量与肺功能及其他CT指标的相关性。LVE/I与第1秒用力呼气量预测值的百分比、第1秒用力肺活量与用力肺活量的比值、残气量与总肺活量的比值呈显著正相关(FEV1%P，R=−0.56p<；0.0001；FEV1/FVC，R=−0.59p<；0.0001；RV/Tlc，R=0.57p<；0.0001)。呼气相LV与呼气相MLD(R=−0.73，p<；0.0001)的相关系数高于吸气相LV与吸气相MLD(R=−0.46，p<；0.01)。LV E/I比值与MLD E/I比值有很强的相关性(R=0.95p<；0.0001)。LV E/I可被认为等同于MLD E/I，反映了气流受限和空气滞留。吸气/呼气CT观察到的肺容量较高的塌陷性表明COPD患者的病情较轻。
To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests, and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease (COPD). 46 smokers (20 females and 26 males; age range 46–81 years), enrolled in the NHLBI Lung Tissue Research Consortium, underwent PFT and chest CT at full inspiration and expiration. Inspiratory and expiratory LV were automatically measured by open-source software, and the expiratory/inspiratory (E/I) ratio of LV was calculated. Mean lung density (MLD) and low attenuation area percent (LAA%,<−950HU) were also measured. Correlations of LV measurements with lung function and other CT indices were evaluated by the Spearman rank correlation test. LV E/I ratio significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1%P, R=−0.56, p<0.0001; FEV1/FVC, R=−0.59, p<0.0001; RV/TLC, R=0.57, p<0.0001, respectively). A higher correlation coefficient was observed between expiratory LV and expiratory MLD (R=−0.73, p<0.0001) than between inspiratory LV and inspiratory MLD (R=−0.46, p<0.01). LV E/I ratio showed a very strong correlation to MLD E/I ratio (R=0.95, p<0.0001). LV E/I ratio can be considered to be equivalent to MLD E/I ratio and to reflect airflow limitation and air-trapping. Higher collapsibility of lung volume, observed by inspiratory/expiratory CT, indicates less severe conditions in COPD.
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